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Mycothiol metabolism
Stable Identifier
R-MTU-870331
Type
Pathway
Species
Mycobacterium tuberculosis
ReviewStatus
5/5
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Mycobacterium tuberculosis biological processes (Mycobacterium tuberculosis)
Mycothiol metabolism (Mycobacterium tuberculosis)
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Mycothiol (MSH), a conjugate of glucosamine, cysteine and inositol, is the Actinobacteria equivalent of glutathione. It serves as a pool for both the unstable cysteine and reduction equivalents. Mycothiol takes part in enzymatic reactions including detoxification of electrophilic compounds, inactivation of reactive oxygen and nitrogen species, reductions, and isomerizations.
M. smegmatis
mutants devoid of MSH are sensitive to oxidative and nitrosative stress, and antibiotics. In
M. tuberculosis
, however, mycothiol synthesis is essential, no null mutants are known. Results from MshD mutants, which have about 1 per cent of MSH, show the importance of mycothiol in environments where antimicrobial factors, including reactive oxygen and reactive nitrogen intermediates, are formed, such as within macrophages (Newton et al, 2008; Rawat and Av-Gay, 2007)
Literature References
PubMed ID
Title
Journal
Year
18772286
Biosynthesis and functions of mycothiol, the unique protective thiol of Actinobacteria
Newton, GL
,
Fahey, RC
,
Buchmeier, N
Microbiol Mol Biol Rev
2008
17286835
Mycothiol-dependent proteins in actinomycetes
Rawat, M
,
Av-Gay, Y
FEMS Microbiol Rev
2007
Participants
Events
Mycothiol biosynthesis
(Mycobacterium tuberculosis)
Mycothiol catabolism
(Mycobacterium tuberculosis)
Mycothiol-dependent detoxification
(Mycobacterium tuberculosis)
mycothiol is oxidized to mycothione
(Mycobacterium tuberculosis)
mycothione is reduced to mycothiol
(Mycobacterium tuberculosis)
Participates
as an event of
Mycobacterium tuberculosis biological processes (Mycobacterium tuberculosis)
Event Information
Go Biological Process
mycothiol metabolic process (0010126)
Authored
Stephan, R (2010-06-07)
Reviewed
Warner, D (2010-11-25)
Created
Stephan, R (2010-06-08)
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