MmpL7 transports PDIM from the cytosol to the cell wall

Stable Identifier
R-MTU-9637589
Type
Reaction [transition]
Species
Mycobacterium tuberculosis
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Among the main constituents of the Mtb outer cell wall are phthiocerol dimycocerosates (PDIM). After biosynthesis PDIM get exported though the inner cell membrane by the phthiocerol dimycocerosate exporter MmpL7 efflux pump (MmpL7) (Cox et al. 1999; Szekely and Cole 2016).

Literature References
PubMed ID Title Journal Year
10573420 Complex lipid determines tissue-specific replication of Mycobacterium tuberculosis in mice

Cox, JS, Chen, B, McNeil, M, Jacobs, WR

Nature 1999
26710752 Mechanistic insight into mycobacterial MmpL protein function

Székely, R, Cole, ST

Mol. Microbiol. 2016
Participants
Participates
Catalyst Activity

fatty acid transmembrane transporter activity of MmpL7 [plasma membrane]

Authored
Reviewed
Created
Cite Us!