SOCS binding to Ghr

Stable Identifier
R-NUL-1169195
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SOCS binding to Ghr
Supprossor of Cytokine Signaling (SOCS)1-3, and the related Cytokine-inducible SH2-containing protein (CIS) all bind tyrosine-phosphorylated GHR (Ram & Waxman 1999, Hansen et al. 1999). SOCS3 binding has been mapped to phosphorylated tyrosines Y338, Y333 (Ram & Waxman 1999), and Y487 (Hansen et al. 1999) in the membrane proximal region of the receptor. SOCS2 and CIS bind to residues Y487 and Y595 (Uyttendaele et al. 2007).
Literature References
PubMed ID Title Journal Year
10551777 Mechanism of inhibition of growth hormone receptor signaling by suppressor of cytokine signaling proteins

Hansen, JA, Lindberg, K, Nielsen, JH, Billestrup, N, Hilton, DJ

Mol Endocrinol 1999
10585430 SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms

Waxman, DJ, Ram, PA

J Biol Chem 1999
Participants
Input
Output
Orthologous Events
SOCS binding to GHR (Homo sapiens)
Reviewed
Herington, AC  (2011-06-13)
Waters, MJ  (2011-06-23)
Created
Jupe, S  (2011-01-13)
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