Proteasomal cleavage of ovalbumin (OVA)

Stable Identifier
Reaction [omitted]
Gallus gallus
SVG |   | PPTX  | SBGN
Proteasomal cleavage of ovalbumin (OVA)

Proteasomes are usually localized to the cytoplasm but are also present in the nucleus and ER. Houde et al. (2003) investigated the distribution of proteasomes in J774 macrophages and observed them on phagosomes. The proteasomes present on phagosomes may not come directly from ER, but instead assemble on phagosomes to play a function at a precise point during phagolysosomal biogenesis. Houde et al. also observed polyubiquitinated proteins on the cytoplasmic side of phagosomes and highlighted the link between the ubiquitination process and proteasomal degradation; translocated peptides are ubiquitinated and processed by the proteasome complex assembled on the cytoplasmic side of phagosomes, leading to the generation of MHC class I binding peptides.

Literature References
PubMed ID Title Journal Year
14508490 Phagosomes are competent organelles for antigen cross-presentation

Houde, M, Brunet, S, Laplante, A, Goyette, G, Bertholet, S, Desjardins, M, Sacks, D, Gagnon, E, Thibault, P, Princiotta, MF

Nature 2003
14508489 ER-phagosome fusion defines an MHC class I cross-presentation compartment in dendritic cells

Guermonprez, P, Van Endert, P, Davoust, J, Amigorena, S, Kleijmeer, M, Saveanu, L

Nature 2003
14561893 Early phagosomes in dendritic cells form a cellular compartment sufficient for cross presentation of exogenous antigens

Ackerman, AL, Kyritsis, C, Cresswell, P, Tampé, R

Proc Natl Acad Sci U S A 2003
Catalyst Activity

endopeptidase activity of Proteasome [cytosol]

Orthologous Events
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