Interaction of soluble ovalbumin with mannose receptor

Stable Identifier
R-NUL-1236951
Type
Reaction
Species
Gallus gallus
Compartment
General
SVG |   | PPTX  | SBGN
Interaction of soluble ovalbumin with mannose receptor

Soluble antigens are presented to dendritic cells (DCs) in some cases by receptor mediated endocytosis or fluid-phase endocytosis. Burgdorf et al. (2008) suggest that there are two different endocytic compartments for antigen processing: one dedicated to MHC class I (early endosomes) and the other one for MHC class II presentation (lysosomes). Sorting of cargo into these different compartments occurs at the plasma membrane and is likely to depend on the type of endocytic receptor the cargo is interacting with (Burgdorf et al. 2008, Zhuang et al. 2006). The mannose receptor (MR) is the best studied receptor that targets soluble antigens to early endosomes but not to lysosomes (Burgdorf et al. 2006). Antigens taken up by the MR are targeted towards a mildly acidic stable early endosomal compartment for exclusive presentation on MHC I molecules (Burgdorf et al. 2008).

Literature References
PubMed ID Title Journal Year
16530046 Ligands for clathrin-mediated endocytosis are differentially sorted into distinct populations of early endosomes

Zhuang, X, Rust, MJ, Lakadamyali, M

Cell 2006
16709836 The mannose receptor mediates uptake of soluble but not of cell-associated antigen for cross-presentation

Kurts, C, Lukacs-Kornek, V, Burgdorf, S

J Immunol 2006
18376402 Spatial and mechanistic separation of cross-presentation and endogenous antigen presentation

Kurts, C, Burgdorf, S, Tampé, R, Kautz, A, Schölz, C

Nat Immunol 2008
18249105 Endocytosis mechanisms and the cell biology of antigen presentation

Kurts, C, Burgdorf, S

Curr Opin Immunol 2008
17463291 Distinct pathways of antigen uptake and intracellular routing in CD4 and CD8 T cell activation

Kurts, C, Knolle, PA, Burgdorf, S, Kautz, A, Bohnert, V

Science 2007
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