SREBP2:SCAP:CopII Coat [endoplasmic reticulum membrane]

Stable Identifier
R-NUL-1655768
Type
Complex
Species
Cricetulus griseus
Compartment
endoplasmic reticulum membrane
Literature References
PubMed ID Title Journal Year
12842885 Reconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and Insigs

Brown, MS, Rawson, RB, Goldstein, JL, Dobrosotskaya, IY

J Biol Chem 2003
17428919 Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins

Brown, MS, Sun, LP, Seemann, J, Goldstein, JL

Proc Natl Acad Sci U S A 2007
15899885 Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro

Brown, MS, Sun, LP, Li, L, Goldstein, JL

J Biol Chem 2005
12193656 Sterols block binding of COPII proteins to SCAP, thereby controlling SCAP sorting in ER

Li, WP, Espenshade, PJ, Yabe, D

Proc Natl Acad Sci U S A 2002
Participants
components
Participates
as an input of
as an output of
Inferred To
SREBP1A,1C,2:SCAP:Cop II Coat [endoplasmic reticulum membrane] (Homo sapiens)
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