PP1CC dephosphorylates TGFBR1

Stable Identifier
R-NUL-2167872
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
PP1CC dephosphorylates TGFBR1
Phosphorylated TGFBR1 is significantly dephosphorylated when incubated with Smad7, PPP1R15A (GADD34) and PP1CC, immunoprecipitated from previously transfected COS1 cells. Dephosphorylation is inhibited by addition of PP1 inhibitor I-1 (Shi et al. 2004).
Literature References
PubMed ID Title Journal Year
14718519 GADD34-PP1c recruited by Smad7 dephosphorylates TGFbeta type I receptor

Shi, X, Sun, C, Cao, X, Yao, D, He, B, Shi, W, Xiong, W

J Cell Biol 2004
Participants
Catalyst Activity

phosphoprotein phosphatase activity of TGFB1:p-TGFBR:Smad7:GADD34:PP1CC:SARA [early endosome membrane]

Orthologous Events
Authored
Reviewed
Created
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