SMURF2 ubiquitinates Smad7 and phosphorylated TGFBR1

Stable Identifier
R-NUL-2176393
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SMURF2 ubiquitinates Smad7 and phosphorylated TGFBR1

When recombinant mouse Smad7 and recombinant human SMURF2, TGFBR2 and TGFBR1 are exogenously expressed in HEK293 cells, SMURF2 (recruited to the activated TGF-beta receptor complex through interaction with Smad7) ubiquitinates Smad7 and may also ubiquitinate TGFBR1. Experimental findings on ubiquitination of TGFBR1 by SMURF2 were inconclusive (Kavsak et al. 2000).

Literature References
PubMed ID Title Journal Year
11163210 Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

Thomsen, GH, Wrana, JL, Bonni, S, Causing, CG, Rasmussen, RK, Zhu, H, Kavsak, P

Mol Cell 2000
Participants
Input
Output
Catalyst Activity

ubiquitin-protein transferase activity of TGFB1:TGFBR2:p-TGFBR1:Smad7:SMURF2 [plasma membrane]

Physical Entity
TGFB1:TGFBR2:p-TGFBR1:Smad7:SMURF2 [plasma membrane] (Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Orthologous Events
SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7 (Homo sapiens)
Authored
Orlic-Milacic, M  (2012-04-05)
Reviewed
Huang, T  (2012-05-14)
Created
Orlic-Milacic, M  (2012-04-02)
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