SMURF1 ubiquitinates Smad7 and phosphorylated TGFBR1

Stable Identifier
R-NUL-2176396
Type
Reaction
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SMURF1 ubiquitinates Smad7 and phosphorylated TGFBR1

When recombinant mouse Smad7 and recombinant human SMURF1, TGFBR1 and TGFBR2 are exogenously expressed in COS1 cells, SMURF1 (recruited to the activated TGF-beta receptor complex through interaction with Smad7) ubiquitinates both Smad7 and TGFBR1 (Ebisawa et al. 2001).

Literature References
PubMed ID Title Journal Year
11278251 Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation

Tanaka, K, Chiba, T, Miyazono, K, Murakami, G, Fukuchi, M, Ebisawa, T, Imamura, T

J Biol Chem 2001
Participants
Input
Output
Catalyst Activity

ubiquitin-protein transferase activity of TGFB1:TGFBR2:p-TGFBR1:Smad7:SMURF1 [plasma membrane]

Physical Entity
TGFB1:TGFBR2:p-TGFBR1:Smad7:SMURF1 [plasma membrane] (Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Orthologous Events
SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7 (Homo sapiens)
Authored
Orlic-Milacic, M  (2012-04-04)
Reviewed
Huang, T  (2012-05-14)
Created
Orlic-Milacic, M  (2012-04-02)
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