SMURF1 ubiquitinates Smad7 and phosphorylated TGFBR1

Stable Identifier
R-NUL-2176396
Type
Reaction
Species
Homo sapiens
Compartment
General
SVG |   | PPTX  | SBGN
SMURF1 ubiquitinates Smad7 and phosphorylated TGFBR1

When recombinant mouse Smad7 and recombinant human SMURF1, TGFBR1 and TGFBR2 are exogenously expressed in COS1 cells, SMURF1 (recruited to the activated TGF-beta receptor complex through interaction with Smad7) ubiquitinates both Smad7 and TGFBR1 (Ebisawa et al. 2001).

Literature References
PubMed ID Title Journal Year
11278251 Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation

Tanaka, K, Chiba, T, Miyazono, K, Murakami, G, Fukuchi, M, Ebisawa, T, Imamura, T

J Biol Chem 2001
Participants
Catalyst Activity

ubiquitin-protein transferase activity of TGFB1:TGFBR2:p-TGFBR1:Smad7:SMURF1 [plasma membrane]

Orthologous Events
Authored
Reviewed
Created
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