Reactome | NEDD4L ubiquitinates Smad7 and TGFBR1

NEDD4L ubiquitinates Smad7 and TGFBR1

Stable Identifier

R-NUL-2176427

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

ReviewStatus

5/5

General

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NEDD4L, recruited to the activated TGF-beta receptor complex by Smad7, ubiquitinates TGFBR1. Ubiquitination of Smad7 by NEDD4L has not been examined in this context (Kuratomi et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
15496141	NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor Miyazono, K, Goto, K, Kuratomi, G, Shinozaki, M, Imamura, T, Komuro, A, Miyazawa, K	Biochem J	2005

Participants

Input

Output

Orthologous Events

SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7 (Homo sapiens)

Authored

Orlic-Milacic, M (2012-04-05)

Reviewed

Huang, T (2012-05-14)

Created

Orlic-Milacic, M (2012-04-02)

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