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NEDD4L binds Smad7
Stable Identifier
R-NUL-2176430
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
General
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In a yeast two-hybrid screen of a HeLa cDNA library using full-length mouse Smad7, NEDD4L was identified as a Smad7 interacting protein. The interaction was confirmed by co-transfection of COS7 cells with recombinant mouse Smad7 and recombinant human NEDD4L (Kuratomi et al. 2005).
Literature References
PubMed ID
Title
Journal
Year
15496141
NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor
Miyazono, K
,
Goto, K
,
Kuratomi, G
,
Shinozaki, M
,
Imamura, T
,
Komuro, A
,
Miyazawa, K
Biochem J
2005
Participants
Input
NEDD4L [nucleoplasm]
(Homo sapiens)
Smad7 [nucleoplasm]
(Mus musculus)
Output
Smad7:NEDD4L [nucleoplasm]
(Homo sapiens)
Orthologous Events
NEDD4L ubiquitin ligase binds SMAD7 (Homo sapiens)
Authored
Orlic-Milacic, M (2012-04-05)
Reviewed
Huang, T (2012-05-14)
Created
Orlic-Milacic, M (2012-04-02)
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