Collagen type X degradation by MMP3, 13

Stable Identifier
Reaction [transition]
Homo sapiens
SVG |   | PPTX  | SBGN
Collagen type X degradation by MMP3, 13

Collagen X forms extended hexagonal networks (Kwan et al. 1991, Jacenko et al. 2001). It's distribution is limited to regions of hypertrophic cartilage destined for degradation during endochondral ossification (Schmid & Conrad 1982). It is also found in areas of surface fibrillation and osteophyte formation during the development of osteoarthritic lesions in articular cartilage (von der Mark et al. 1992). In Timp3 knockout mice type X collagen was observed mostly in areas of articular cartilage that stained strongly for collagen cleavage products, suggesting that deposition of type X collagen might be a damage repair mechanism (Sahebjam et al. 2007). Mutations in the gene COL10A1 are associated with Schmid/Japanese type metaphyseal chondrodysplasia (SMCD) (Warman et al. 1993, Ho et al. 2007, Woelfle et al. 2011).

Type X collagen is degraded by MMP1 (Schmid et al. 1986, Welgus et al. 1990, Cole et al. 1993), MMP2 (Cole et al. 1993, Welgus et al. 1990), MMP3 (Wu et al. 1991), MMP13 (Knauper et al. 1997) and ELANE (neutrophil elastase - Kittelberger et al. 1992).

Literature References
PubMed ID Title Journal Year
2005102 Sites of stromelysin cleavage in collagen types II, IX, X, and XI of cartilage

Lark, MW, Chun, LE, Eyre, DR, Wu, JJ

J Biol Chem 1991
9065415 The role of the C-terminal domain of human collagenase-3 (MMP-13) in the activation of procollagenase-3, substrate specificity, and tissue inhibitor of metalloproteinase interaction

O'Shea, M, Cowell, S, Morris, H, Smith, B, Zardi, L, López-Otin, C, Knäuper, V, Murphy, G

J Biol Chem 1997
Catalyst Activity

metalloendopeptidase activity of MMP3,13 [extracellular region]

Orthologous Events
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