KAT5 HAT complex acetylates TCF4 (ITF-2) gene at histone H4

Stable Identifier
Reaction [transition]
Homo sapiens
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KAT5 HAT complex acetylates TCF4 (ITF-2) gene at histone H4

ChIP studies in HEK293 cells show that RUVBL1(TIP49), TRRAP, TCF7L2(TCF4) and the histone acetyltransferase KAT5 (TIP60) are present at the TCF4/ITF-2 gene in vivo. In rat epithelial cells, acetylation of histone H4 at the TCF4 (ITF-2) promoter is significantly reduced upon expression of a dominant negative version of RUVBL1 (TIP49), consistent with a role of a TIP49-containing HAT complex in activating WNT-dependent gene expression (Feng et al, 2003; Kolligs et al, 2002).

Literature References
PubMed ID Title Journal Year
12086873 ITF-2, a downstream target of the Wnt/TCF pathway, is activated in human cancers with beta-catenin defects and promotes neoplastic transformation

Kolligs, FT, Nieman, MT, Winer, I, Hu, G, Van Mater, D, Feng, Y, Smith, IM, Wu, R, Zhai, Y, Cho, KR, Fearon, ER

Cancer Cell 2002
14695187 TIP49 regulates beta-catenin-mediated neoplastic transformation and T-cell factor target gene induction via effects on chromatin remodeling

Feng, Y, Lee, N, Fearon, ER

Cancer Res. 2003
Catalyst Activity

histone acetyltransferase activity of LEF:CTNNB1:RUVBL1:TRRAP:KAT5 [nucleoplasm]

Orthologous Events
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