sFrp binds Wnt3a and inhibits WNT-FZD binding

Stable Identifier
R-NUL-3772439
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
sFrp binds Wnt3a and inhibits WNT-FZD binding
Mouse Wnt3a binds directly with nanomolar affinities to four sFRPs that were tested (mouse sFRP2 and 3 and human sFRP1 and 4), as assessed by surface plasmon resonance. Despite this, only sFRP1 and 2 were able to inhibit Wnt3a signaling in mouse L cells. sFRP2 was also shown to inhibit Wnt3a dependent mesoderm formation in mouse ES cells (Wawrzak et al, 2007).
Literature References
PubMed ID Title Journal Year
17462603 Wnt3a binds to several sFRPs in the nanomolar range

de Genst, E, Wawrzak, D, Hendrickx, M, Métioui, M, Leyns, L, Willems, E

Biochem. Biophys. Res. Commun. 2007
Participants
Input
Output
Orthologous Events
sFRP binds WNT3A and inhibits WNT:FZD binding (Homo sapiens)
Authored
Rothfels, K  (2013-05-30)
Reviewed
Rajakulendran, N  (2014-01-22)
van Amerongen, R  (2014-02-15)
Kikuchi, A  (2014-04-22)
Created
Rothfels, K  (2013-06-25)
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