Rat Dvl is phosophorylated upon Wnt binding

Stable Identifier
R-NUL-3858478
Type
Reaction [transition]
Species
Mus musculus
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Rat Dvl is phosophorylated upon Wnt binding
Endogenous DVL2 and 3 are phosphorylated upon stimulation of Rat2 fibroblast cells with CM from cells expressing Wnt1, 3a, 4, 5a or 11.
Literature References
PubMed ID Title Journal Year
15143170 Wnt proteins induce dishevelled phosphorylation via an LRP5/6- independent mechanism, irrespective of their ability to stabilize beta-catenin

Brennan, KR, González-Sancho, JM, Brown, AM, Castelo-Soccio, LA

Mol. Cell. Biol. 2004
Participants
Input
Output
Catalyst Activity

protein serine/threonine kinase activity of unknown kinase [cytosol]

Physical Entity
unknown kinase [cytosol] (Rattus norvegicus)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
Unknown kinase phosphorylates p-DVL (Homo sapiens)
WNT-dependent phosphorylation of DVL (Homo sapiens)
Authored
Rothfels, K  (2013-06-28)
Reviewed
Kikuchi, A  (2013-11-13)
Created
Rothfels, K  (2013-07-10)
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