Fyn binds NCAM1

Stable Identifier
R-NUL-420386
Type
Reaction [binding]
Species
Mus musculus
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Fyn binds NCAM1
Fyn constitutively associates with the 140 kD isoform of NCAM1 in the plasma membrane, probably indirectly. Fyn is attached to the lipid raft membrane compartment via palmitoylation and is inactivated by tyrosine phosphorylation (Y531) within its C-terminal regulatory region. Fyn kinase has two well-known phosphorylation sites which affect its activity in opposite ways. The phosphorylation of Tyr531 located in the C-terminus of the protein inhibits the Fyn kinase activity, due to the binding of this tyrosine residue to the SH2 domain of the protein, which stabilizes its catalytically inactive conformation.
Literature References
PubMed ID Title Journal Year
7962063 NCAM-dependent neurite outgrowth is inhibited in neurons from Fyn-minus mice

Soriano, P, Beggs, HE, Maness, PF

J Cell Biol 1994
9079653 NCAM140 interacts with the focal adhesion kinase p125(fak) and the SRC-related tyrosine kinase p59(fyn)

Hemperly, JJ, Baragona, SC, Beggs, HE, Maness, PF

J Biol Chem 1997
Participants
Input
Output
Orthologous Events
Fyn binds NCAM1 (Homo sapiens)
Authored
Garapati, P V  (2009-02-24)
Reviewed
Walmod, PS  (2009-05-26)
Maness, PF  (2009-05-26)
Created
Garapati, P V  (2009-05-11)
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