RFzd binds trimeric G-proteins

Stable Identifier
R-NUL-4551534
Type
Reaction [binding]
Species
Mus musculus
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
RFzd binds trimeric G-proteins
Stimulation of mouse teratocarcinoma cells expressing rat Fzd2 with XWnt5a conditioned medium induces formation of primitive endoderm (PE), a readout for WNT signaling. PE formation is abolished by pre-treatment of cells with pertussis toxin, indicating the involvement of G-proteins (Liu et al, 1999). Similar studies using the Fzd2:beta-adrenergic receptor chimeric protein in zebrafish support a role for G-protein and phosphoinositol signaling downstream of non-canonical WNTs (Slusarski et al, 1997; Liu et al, 1999)
Literature References
PubMed ID Title Journal Year
9389482 Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling

Corces, VG, Slusarski, DC, Moon, RT

Nature 1997
10588714 Activation of a frizzled-2/beta-adrenergic receptor chimera promotes Wnt signaling and differentiation of mouse F9 teratocarcinoma cells via Galphao and Galphat

Yang-Snyder, J, Liu, X, Liu, T, Moon, RT, Wang, H, Slusarski, DC, Malbon, CC

Proc. Natl. Acad. Sci. U.S.A. 1999
Participants
Input
Output
Orthologous Events
FZD recruits trimeric G-proteins (Homo sapiens)
Authored
Rothfels, K  (2013-09-03)
Reviewed
Kikuchi, A  (2013-11-13)
Created
Rothfels, K  (2013-09-14)
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