Shh is released from the plasma membrane by ADAM17-mediated cleavage

Stable Identifier
R-NUL-5362792
Type
Reaction [transition]
Species
Homo sapiens
Compartment
General
SVG |   | PPTX  | SBGN
Shh is released from the plasma membrane by ADAM17-mediated cleavage

Coexpression of mouse Shh and human ADAM17 in Bosc23 cells results in the release of a soluble Shh Np lacking the C-terminal cholesterol moiety and the N-terminal palmitoylation. Hh shedding is dependent on ADAM17, as inactivation of the metalloprotease by mutation of the catalytic site or by siRNA-mediated depletion abrogates the ligand release (Dierker et al, 2009).

Literature References
PubMed ID Title Journal Year
19176481 Heparan sulfate-modulated, metalloprotease-mediated sonic hedgehog release from producing cells

Dierker, T, Dreier, R, Petersen, A, Bordych, C, Grobe, K

J. Biol. Chem. 2009
Participants
Catalyst Activity

metalloendopeptidase activity of ADAM17 [plasma membrane]

Orthologous Events
Authored
Reviewed
Created
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