Cxxc4 binds DVL to prevent AXIN binding

Stable Identifier
R-NUL-5368583
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Cxxc4 binds DVL to prevent AXIN binding
Cxxc4 was identified as Idax in a two-hybrid screen of a rat library with a human DVL1 bait. Idax forms a complex with DVL in vivo and competes with AXIN for DVL binding. Expression of Idax in L-cells abrogates the WNT3a-induced expression of a TCF-dependent reporter gene, supporting a role for Idax as a negative regulator of WNT target gene expression (Hino et al, 2001).
Literature References
PubMed ID Title Journal Year
10944533 Inhibition of Wnt signaling pathway by a novel axin-binding protein

Kikuchi, A, Kadoya, T, Asashima, M, Hinoi, T, Michiue, T, Kishida, S, Fukui, A

J. Biol. Chem. 2000
Participants
Input
Output
Orthologous Events
CXXC4 binds DVL to prevent AXIN binding (Homo sapiens)
Authored
Kikuchi, A  (2014-04-22)
Created
Rothfels, K  (2014-04-28)
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