SCF(beta-TrCP) ubiquitinates p-Gli2

Stable Identifier
R-NUL-5610711
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SCF(beta-TrCP) ubiquitinates p-Gli2
mGli2 is polyubiquitinated when overexpressed in HEK293 cells with myc-ubiquitin, and is degraded in a phosphorylation-dependent manner by beta TrCP. beta TrCP interacts directly with phosphorylated Gli2 as assessed by co-precipitation from HEK293 cell lysates and by in vitro binding assays (Pan et al, 2006).
Literature References
PubMed ID Title Journal Year
16611981 Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation

Pan, Y, Bai, CB, Wang, B, Joyner, AL

Mol. Cell. Biol. 2006
Participants
Input
Output
Catalyst Activity

ubiquitin-protein transferase activity of Btrc,Fbxw11 [cytosol]

Physical Entity
Btrc,Fbxw11 [cytosol] (Mus musculus)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Orthologous Events
SCF(beta-TrCP) ubiquitinates p-GLI2 (Homo sapiens)
Authored
Rothfels, K  (2014-05-07)
Reviewed
Liu, Y C  (2014-08-01)
Created
Rothfels, K  (2014-07-23)
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