GSK3 phosphorylates p-Gli2

Stable Identifier
R-NUL-5610714
Type
Reaction [transition]
Species
Mus musculus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
GSK3 phosphorylates p-Gli2
PKA-phosphorylated Gli2 from mouse cells is further phosphorylated in vitro by rabbit Gsk3b at three or more serine residues. This phosphorylation is required for Gli2 processing and degradation by the proteasome (Pan et al, 2006).
Literature References
PubMed ID Title Journal Year
16611981 Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation

Pan, Y, Bai, CB, Wang, B, Joyner, AL

Mol. Cell. Biol. 2006
Participants
Input
Output
Catalyst Activity

protein serine/threonine kinase activity of Gsk3b [cytosol]

Physical Entity
Gsk3b [cytosol] (Oryctolagus cuniculus)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
GSK3 phosphorylates p-GLI2 (Homo sapiens)
Authored
Rothfels, K  (2014-05-07)
Reviewed
Liu, Y C  (2014-08-01)
Created
Rothfels, K  (2014-07-23)
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