Gli2is degraded by the proteasome

Stable Identifier
R-NUL-5610751
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Gli2is degraded by the proteasome
Gli2 is degraded in a proteasome-dependent manner after phosphorylation and ubiquitination (Pan et al, 2006).
Literature References
PubMed ID Title Journal Year
16611981 Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation

Pan, Y, Bai, CB, Wang, B, Joyner, AL

Mol. Cell. Biol. 2006
Participants
Input
Output
Catalyst Activity

endopeptidase activity of 26S proteasome [cytosol]

Physical Entity
26S proteasome [cytosol] (Homo sapiens)
Activity
endopeptidase activity (GO:0004175)
Orthologous Events
GLI2 is degraded by the proteasome (Homo sapiens)
Authored
Rothfels, K  (2014-05-07)
Reviewed
Liu, Y C  (2014-08-01)
Created
Rothfels, K  (2014-07-23)
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