Recruitment of CSB, G9a, and NuRD to the rRNA promoter

Stable Identifier
Reaction [binding]
Homo sapiens
SVG |   | PPTX  | SBGN
Recruitment of CSB, G9a, and NuRD to the rRNA promoter

Transcription Termination Factor-I (TTF-I) is a sequence-specific binding protein that binds sites 5' (Tsp and T0 sites) and 3' (T1-10 site) of rRNA genes. When TTF-I is bound to the promoter-proximal T0 site TTF-I recruits either Cockayne Syndrome Protein CSB, Histone Methylase G9a, and NuRD to activate expression (Yuan et al. 2007) or Nucleolar Remodeling Complex (NoRC) to repress expression. How one is selected over the other is unknown. The NuRD complex activates transcription by shifting the position of one nucleosome in the promoter region of an rRNA gene (Xie et al. 2012).

Literature References
PubMed ID Title Journal Year
22570494 The chromatin remodeling complex NuRD establishes the poised state of rRNA genes characterized by bivalent histone modifications and altered nucleosome positions

Xie, W, Ling, T, Zhou, Y, Feng, W, Zhu, Q, Stunnenberg, HG, Grummt, I, Tao, W

Proc. Natl. Acad. Sci. U.S.A. 2012
17707230 Activation of RNA polymerase I transcription by cockayne syndrome group B protein and histone methyltransferase G9a

Yuan, X, Feng, W, Imhof, A, Grummt, I, Zhou, Y

Mol Cell 2007
Orthologous Events
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