Cdk5:p25 phosphorylates FOXO3

Stable Identifier
R-NUL-8870566
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Cdk5:p25 phosphorylates FOXO3
Recombinant mouse Cdk5 in complex with recombinant mouse p25 phosphorylates recombinant human FOXO3 on serine residues S43, S173, S294 and S325 (Shi et al. 2016).
Literature References
PubMed ID Title Journal Year
28157684 Cdk5-Foxo3 axis: initially neuroprotective, eventually neurodegenerative in Alzheimer's disease models

Shi, C, Viccaro, K, Lee, HG, Shah, K

J Cell Sci 2016
Participants
Input
Output
Catalyst Activity

protein serine/threonine kinase activity of Cdk5:p25 [cytosol]

Physical Entity
Cdk5:p25 [cytosol] (Mus musculus)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
CDK5:p25 phosphorylates FOXO3 (Homo sapiens)
Authored
Shah, K  (2016-02-23)
Created
Orlic-Milacic, M  (2016-05-11)
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