Slc8a3 (NCX3) exchanges sodium (cytosol) for calcium (mitochondrial intermembrane space)

Stable Identifier
R-NUL-8951809
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Slc8a3 (NCX3) exchanges sodium (cytosol) for calcium (mitochondrial intermembrane space)

Rat Slc8a3 in a complex with mouse Akap1 exchanges cytosolic sodium ions for divalent calcium from the mitochondrial intermembrane space resulting in an efflux of calcium from the mitochondrion (Scorziello et al. 2013).

Literature References
PubMed ID Title Journal Year
24101730 NCX3 regulates mitochondrial Ca(2+) handling through the AKAP121-anchored signaling complex and prevents hypoxia-induced neuronal death

Adornetto, A, Scorziello, A, Carlucci, A, Boscia, F, Di Renzo, G, Annunziato, L, Lignitto, L, Polishchuk, EV, Secondo, A, Sisalli, MJ, Feliciello, A, Savoia, C, Molinaro, P, Polishchuk, RS, Esposito, A

J. Cell. Sci. 2013
Participants
Catalyst Activity

calcium:sodium antiporter activity of Slc8a3:Akap1 [mitochondrial outer membrane]

Orthologous Events
Authored
Reviewed
Created
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