The receptor for Thymic stromal lymphopoietin (TSLP) consists of Cytokine receptor-like factor 2 (CRLF2, TSLPR) and Interleukin-7 receptor subunit alpha (IL7R). Following binding of TSLP Signal transducer and activator of transcription 5A or 5B (STAT5A and STAT5B, or as a brief STAT5) and Signal transducer and activator of transcription 3 (STAT3) are phosphorylated (in Ba/F3 cell line).Phosphorylation of STAT5 and STAT3 by human TSLP has only been detected on cells expressing both receptors IL7R and TSLPR (Reche et al.2001).This is a black box event since there are no experimental details confirming binding of STAT3 and STAT5 to the receptor complex.
Bazan, JF, Johnston, J, Zurawski, SM, de Waal Malefyt, R, Gorman, DM, Liu, MR, Liu, YJ, Clifford, T, Kastelein, RA, Travis, M, Spits, H, Soumelis, V, Reche, PA
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