Hey1 gene expression is positively regulated by Notch3

Stable Identifier
R-NUL-9014136
Type
Reaction [BlackBoxEvent]
Species
Mus musculus
Compartment
nucleoplasm
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Hey1 gene expression is positively regulated by Notch3

A recombinant Notch3 coactivator complex composed of mouse Notch3 and Rbpj and (since mouse proteins are expressed in rat cells) rat Maml (Maml1 , Maml2 or Maml3) positively regulates transcription of the rat Hey1 gene (Wang et al. 2002).

Literature References
PubMed ID Title Journal Year
11971902 Coordinate Notch3-hairy-related transcription factor pathway regulation in response to arterial injury. Mediator role of platelet-derived growth factor and ERK

Prince, CZ, Wang, W, Pollman, MJ, Mou, Y, Campos, AH

J. Biol. Chem. 2002
Participants
Input
Output
This event is regulated
Positively by
Regulator
Notch3 coactivator complex [nucleoplasm] (Mus musculus)
Orthologous Events
HEY1 gene expression is positively regulated by NOTCH3 and STAT1 (Homo sapiens)
Authored
Orlic-Milacic, M  (2017-09-20)
Reviewed
Haw, R  (2017-10-30)
Created
Orlic-Milacic, M  (2017-07-26)
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