Cdk5 phosphorylates Ntrk2

Stable Identifier
R-NUL-9032961
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Cdk5 phosphorylates Ntrk2
In rat cortical neurons, Cdk5 phosphorylates BDNF-activated Ntrk2 (TrkB) receptor on serine residue S478 (Cheung et al. 2007).
Literature References
PubMed ID Title Journal Year
17341134 Cdk5 is involved in BDNF-stimulated dendritic growth in hippocampal neurons

Ng, YP, Ip, NY, Chin, WH, Cheung, ZH, Chen, Y

PLoS Biol. 2007
Participants
Input
Output
Catalyst Activity

protein serine/threonine kinase activity of BDNF:p-5Y-Ntrk2 homodimer:p-Y15-Cdk5:p35 [plasma membrane]

Physical Entity
BDNF:p-5Y-Ntrk2 homodimer:p-Y15-Cdk5:p35 [plasma membrane] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
CDK5 phosphorylates NTRK2 (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-01-05)
Reviewed
Castrén, E  (2018-02-13)
Antila, H  (2018-02-13)
Created
Orlic-Milacic, M  (2017-12-20)
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