Ntrk2 promotes Tiam1 phosphorylation

Stable Identifier
R-NUL-9033333
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
General
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Ntrk2 promotes Tiam1 phosphorylation
Mouse Ntrk2 (Trkb), activated by recombinant human BDNF, and phosphorylated by Cdk5 at serine residue S478, promotes phosphorylation of mouse Tiam1 at tyrosine residue Y829 (Lai et al. 2012).
Literature References
PubMed ID Title Journal Year
23064382 TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory

Palko, ME, Xu, P, Ip, NY, Cheung, MC, Lok, KC, Cheung, ZH, Xie, H, Tessarollo, L, Lai, KO, Yung, WH, Liang, Z, Wong, AS

Nat. Neurosci. 2012
Participants
Input
Output
Catalyst Activity

protein tyrosine kinase activity of BDNF:p-5Y,S478-Ntrk2 homodimer:Tiam1 [plasma membrane]

Physical Entity
BDNF:p-5Y,S478-Ntrk2 homodimer:Tiam1 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
NTRK2 promotes TIAM1 phosphorylation (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-01-05)
Reviewed
Castrén, E  (2018-02-13)
Antila, H  (2018-02-13)
Created
Orlic-Milacic, M  (2017-12-20)
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