Ntrk2 and Cdk5 promote activation of Rac1 by Tiam1

Stable Identifier
R-NUL-9033341
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Ntrk2 and Cdk5 promote activation of Rac1 by Tiam1
In cultured mouse neurons, stimulated by recombinant human BDNF, phosphorylation of mouse Ntrk2 by Cdk5 is needed for BDNF-induced activation of Rac1 by Tiam1 (Lai et al. 2012).
Literature References
PubMed ID Title Journal Year
23064382 TrkB phosphorylation by Cdk5 is required for activity-dependent structural plasticity and spatial memory

Palko, ME, Xu, P, Ip, NY, Cheung, MC, Lok, KC, Cheung, ZH, Xie, H, Tessarollo, L, Lai, KO, Yung, WH, Liang, Z, Wong, AS

Nat. Neurosci. 2012
Participants
Input
Output
Catalyst Activity

guanyl-nucleotide exchange factor activity of BDNF:p-5Y,S478-Ntrk2 homodimer:p-Y829-Tiam1 [plasma membrane]

Physical Entity
BDNF:p-5Y,S478-Ntrk2 homodimer:p-Y829-Tiam1 [plasma membrane] (Homo sapiens)
Activity
guanyl-nucleotide exchange factor activity (GO:0005085)
Orthologous Events
NTRK2 and CDK5 promote activation of RAC1 by TIAM1 (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-01-05)
Reviewed
Castrén, E  (2018-02-13)
Antila, H  (2018-02-13)
Created
Orlic-Milacic, M  (2017-12-20)
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