AMPK phosphorylates Mapt

Stable Identifier
R-NUL-9619534
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
AMPK phosphorylates Mapt
Recombinant rat AMPK complex, composed of AMPK-alpha1 (Prkaa1), AMPK-beta1 (Prkab1) and AMPK-gamma1 (Prkag1), phosphorylates recombinant human Tau protein on serine residues S262, S356 and S396 (Thornton et al. 2011, Mairet-Coello et al. 2013).
Literature References
PubMed ID Title Journal Year
23583109 The CAMKK2-AMPK kinase pathway mediates the synaptotoxic effects of Aβ oligomers through Tau phosphorylation

Mairet-Coello, G, Courchet, J, Pieraut, S, Courchet, V, Maximov, A, Polleux, F

Neuron 2013
21204788 AMP-activated protein kinase (AMPK) is a tau kinase, activated in response to amyloid β-peptide exposure

Thornton, C, Bright, NJ, Sastre, M, Muckett, PJ, Carling, D

Biochem. J. 2011
Participants
Input
Output
Catalyst Activity

protein serine/threonine kinase activity of p-T183-AMPKalpha1beta1gamma1 [cytosol]

Physical Entity
p-T183-AMPKalpha1beta1gamma1 [cytosol] (Rattus norvegicus)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
AMPK phosphorylates MAPT (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-10-10)
Reviewed
Yi, F  (2018-11-02)
Hansen, KB  (2018-11-02)
Created
Orlic-Milacic, M  (2018-09-18)
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