PDPK1 phosphorylates Rps6ka2

Stable Identifier
R-NUL-9620024
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
PDPK1 phosphorylates Rps6ka2
Recombinant human PDPK1 phosphorylates recombinant mouse Rps6ka3 (Rsk2) on serine residue S227 (Jensen et al. 1999).
Literature References
PubMed ID Title Journal Year
10480933 90-kDa ribosomal S6 kinase is phosphorylated and activated by 3-phosphoinositide-dependent protein kinase-1

Frödin, M, Krag, TO, Gammeltoft, S, Jensen, CJ, Buch, MB, Hemmings, BA

J Biol Chem 1999
Participants
Input
Output
Catalyst Activity

protein serine/threonine kinase activity of PDPK1:PIP3,PDPK1:PIP2 [plasma membrane]

Physical Entity
PDPK1:PIP3,PDPK1:PIP2 [plasma membrane] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
PDPK1 phosphorylates RSKs (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-10-10)
Reviewed
Hansen, KB  (2018-11-02)
Yi, F  (2018-11-02)
Created
Orlic-Milacic, M  (2018-09-20)
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