p-7Y ALK dimer phosphorylates Frs2

Stable Identifier
R-NUL-9700161
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
p-7Y ALK dimer phosphorylates Frs2
Frs2 is phosphorylated in an ALK kinase-dependent manner when Frs2 and ALK are co-expressed in HEK293 cells (Degoutin et al, 2007).
Literature References
PubMed ID Title Journal Year
17274988 ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation

Vigny, M, Degoutin, J, Gouzi, JY

FEBS Lett. 2007
Participants
Input
Output
Catalyst Activity

protein tyrosine kinase activity of p-7Y ALK dimer:Frs2 [plasma membrane]

Physical Entity
p-7Y ALK dimer:Frs2 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
Active ALK phosphorylates FRS2 (Homo sapiens)
Authored
Rothfels, K  (2021-03-30)
Reviewed
Inghirami, G  (2021-05-04)
Created
Rothfels, K  (2020-09-14)
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