Active ALK phosphorylates Src

Stable Identifier
R-NUL-9700655
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Active ALK phosphorylates Src
Endogenous Src is phosphorylated when co-expressed in Ba/F3 cells with the human NPM-ALK fusion in a manner that depends on ALK kinase activity (Cussac et al, 2004).
Literature References
PubMed ID Title Journal Year
14563642 Nucleophosmin-anaplastic lymphoma kinase of anaplastic large-cell lymphoma recruits, activates, and uses pp60c-src to mediate its mitogenicity

Roche, S, Duyster, J, Greenland, C, Morris, SW, Delsol, G, Bai, RY, Payrastre, B, Allouche, M, Cussac, D

Blood 2004
Participants
Input
Output
Catalyst Activity

protein tyrosine kinase activity of Active ALK:Src [plasma membrane]

Physical Entity
Active ALK:Src [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
Active ALK phosphorylates SRC (Homo sapiens)
Authored
Rothfels, K  (2021-03-30)
Reviewed
Inghirami, G  (2021-05-04)
Created
Rothfels, K  (2020-09-16)
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