Reactome | Gnb1:GNG2:PLCB2:Ca2+ hydrolyzes PI(4,5)P2 to I(1,4,5)P3 and DAG

Gnb1:GNG2:PLCB2:Ca2+ hydrolyzes PI(4,5)P2 to I(1,4,5)P3 and DAG

Stable Identifier

R-NUL-9717576

Type

Reaction [transition]

Species

Bos taurus

Compartment

plasma membrane

ReviewStatus

5/5

General

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Gnb1:GNG2:PLCB2:Ca2+ hydrolyzes PI(4,5)P2 to I(1,4,5)P3 and DAG

The binding of the gustducin beta-gamma complex (Gnb1,3:GNG13) to Phospholipase beta-2 (PLCB2) activates its catalytic activity, resulting in hydrolysis of phosphoinositol 4,5-bisphosphate (PI(4,5)P2) to yield diacylglycerol and inositol 1,4,5-trisphosphate (I(1,4,5)P3) (Romoser et al. 1996, Sankaran et al. 1998, Fogg et al. 2001, Yoshikawa et al. 2001, Bonacci et al. 2005).

Literature References

PubMed ID	Title	Journal	Year
9507029	Identification of a structural element in phospholipase C beta2 that interacts with G protein betagamma subunits Wu, D, Sankaran, B, Osterhout, J, Smrcka, AV	J Biol Chem	1998
11145956	Characterization of a phospholipase C beta 2-binding site near the amino-terminal coiled-coil of G protein beta gamma subunits Yoshikawa, DM, Hatwar, M, Bresciano, K, Smrcka, AV	J Biol Chem	2001
8810260	Phospholipase C beta2 association with phospholipid interfaces assessed by fluorescence resonance energy transfer. G protein betagamma subunit-mediated translocation is not required for enzyme activation Ball, R, Smrcka, AV, Romoser, V	J Biol Chem	1996
15611108	Regulatory interactions between the amino terminus of G-protein betagamma subunits and the catalytic domain of phospholipase Cbeta2 Smrcka, AV, Bonacci, TM, Ghosh, M, Malik, S	J Biol Chem	2005
11546822	Role of the gamma subunit prenyl moiety in G protein beta gamma complex interaction with phospholipase Cbeta Azpiazu, I, Fogg, VC, Scarlata, S, Smrcka, A, Linder, ME, Gautam, N	J Biol Chem	2001

Participants

Input

Output

Catalyst Activity

phosphatidylinositol phospholipase C activity of Gnb1:GNG2:PLCB2:Ca2+ [plasma membrane]

Physical Entity

Gnb1:GNG2:PLCB2:Ca2+ [plasma membrane] (Bos taurus)

Activity

phosphatidylinositol phospholipase C activity (GO:0004435)

Orthologous Events

GNB1,3:GNG13:PLCB2:Ca2+ hydrolyzes PI(4,5)P2 to I(1,4,5)P3 and DAG (Homo sapiens)

Authored

May, B (2021-03-10)

Reviewed

Jiang, P (2021-08-08)

Created

May, B (2021-03-12)

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