Reactome | TUBB4A [cytosol]

TUBB4A [cytosol]

Stable Identifier

R-PFA-190588

Type

Protein [EntityWithAccessionedSequence]

Species

Plasmodium falciparum

Compartment

cytosol

Synonyms

Q7KQL5

Locations in the PathwayBrowser

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Cell Cycle (Plasmodium falciparum)

- Cell Cycle, Mitotic (Plasmodium falciparum)
  - M Phase (Plasmodium falciparum)
    - Mitotic Prometaphase (Plasmodium falciparum)
      - EML4 and NUDC in mitotic spindle formation (Plasmodium falciparum)
        
        EML4 binds to microtubules (Plasmodium falciparum)
        
        EML4 homotrimer:Microtubule [cytosol] (Plasmodium falciparum)
        
        Microtubule [cytosol] (Plasmodium falciparum)
        
        Microtubule protofilament [cytosol] (Plasmodium falciparum)
        
        alpha-beta tubulin dimer [cytosol] (Plasmodium falciparum)
        
        beta-tubulin:GDP [cytosol] (Plasmodium falciparum)
        
        beta-tubulin [cytosol] (Plasmodium falciparum)
        
        TUBB4A [cytosol] (Plasmodium falciparum)
        
        Microtubule [cytosol] (Plasmodium falciparum)
        
        Microtubule protofilament [cytosol] (Plasmodium falciparum)
        
        alpha-beta tubulin dimer [cytosol] (Plasmodium falciparum)
        
        beta-tubulin:GDP [cytosol] (Plasmodium falciparum)
        
        beta-tubulin [cytosol] (Plasmodium falciparum)
        
        TUBB4A [cytosol] (Plasmodium falciparum)

Metabolism of proteins (Plasmodium falciparum)

- Post-translational protein modification (Plasmodium falciparum)
  - Carboxyterminal post-translational modifications of tubulin (Plasmodium falciparum)
    - TTLLs polyglutamylate tubulin (Plasmodium falciparum)
      - Microtubule [cytosol] (Plasmodium falciparum)
        
        Microtubule protofilament [cytosol] (Plasmodium falciparum)
        
        alpha-beta tubulin dimer [cytosol] (Plasmodium falciparum)
        
        beta-tubulin:GDP [cytosol] (Plasmodium falciparum)
        
        beta-tubulin [cytosol] (Plasmodium falciparum)
        
        TUBB4A [cytosol] (Plasmodium falciparum)
      - Polyglutamylated microtubule [cytosol] (Plasmodium falciparum)
        
        Microtubule protofilament [cytosol] (Plasmodium falciparum)
        
        alpha-beta tubulin dimer [cytosol] (Plasmodium falciparum)
        
        beta-tubulin:GDP [cytosol] (Plasmodium falciparum)
        
        beta-tubulin [cytosol] (Plasmodium falciparum)
        
        TUBB4A [cytosol] (Plasmodium falciparum)

Organelle biogenesis and maintenance (Plasmodium falciparum)

- Cilium Assembly (Plasmodium falciparum)
  - ATAT acetylates microtubules (Plasmodium falciparum)
    - Microtubule [cytosol] (Plasmodium falciparum)
      - Microtubule protofilament [cytosol] (Plasmodium falciparum)
        
        alpha-beta tubulin dimer [cytosol] (Plasmodium falciparum)
        
        beta-tubulin:GDP [cytosol] (Plasmodium falciparum)
        
        beta-tubulin [cytosol] (Plasmodium falciparum)
        
        TUBB4A [cytosol] (Plasmodium falciparum)
    - acetylated microtubule [cytosol] (Plasmodium falciparum)
      - acetylated microtubule protofilament [cytosol] (Plasmodium falciparum)
        
        Ac K40 alpha tubulin-beta tubulin dimer [cytosol] (Plasmodium falciparum)
        
        beta-tubulin:GDP [cytosol] (Plasmodium falciparum)
        
        beta-tubulin [cytosol] (Plasmodium falciparum)
        
        TUBB4A [cytosol] (Plasmodium falciparum)
  - HDAC6 deacetylates microtubules (Plasmodium falciparum)
    - Microtubule [cytosol] (Plasmodium falciparum)
      - Microtubule protofilament [cytosol] (Plasmodium falciparum)
        
        alpha-beta tubulin dimer [cytosol] (Plasmodium falciparum)
        
        beta-tubulin:GDP [cytosol] (Plasmodium falciparum)
        
        beta-tubulin [cytosol] (Plasmodium falciparum)
        
        TUBB4A [cytosol] (Plasmodium falciparum)
    - acetylated microtubule [cytosol] (Plasmodium falciparum)
      - acetylated microtubule protofilament [cytosol] (Plasmodium falciparum)
        
        Ac K40 alpha tubulin-beta tubulin dimer [cytosol] (Plasmodium falciparum)
        
        beta-tubulin:GDP [cytosol] (Plasmodium falciparum)
        
        beta-tubulin [cytosol] (Plasmodium falciparum)
        
        TUBB4A [cytosol] (Plasmodium falciparum)

External Reference Information

External Reference

UniProt:Q7KQL5

Reference Genes

BioGPS Gene:810242

ENSEMBL:PF10_0084

KEGG Gene (Plasmodium falciparum):PF3D7_1008700

Monarch:810242

NCBI Gene:810242

PlasmoDB:PF10_0084

Reference Transcript

RefSeq:XM_001347333.1

Participates

as a candidate of

beta-tubulin [cytosol] (Plasmodium falciparum)

Other forms of this molecule

Polyglycyl-TUBB1 [cytosol]

Polyglycyl-TUBB3 [cytosol]

Polyglycyl-TUBB2A [cytosol]

Polyglycyl-TUBB6 [cytosol]

Polyglycyl-TUBB4A [cytosol]

Polyglutamyl-TUBB3 [cytosol]

Polyglutamyl-TUBB2A [cytosol]

Polyglutamyl-TUBB4A [cytosol]

Polyglutamyl-TUBB1 [cytosol]

Polyglutamyl-TUBB6 [cytosol]

TUBB4A [axonemal microtubule]

TUBB4B [axonemal microtubule]

TUBB6 [axonemal microtubule]

TUBB3 [axonemal microtubule]

TUBB1 [axonemal microtubule]

TUBB4B [extracellular region]

TUBB [azurophil granule lumen]

TUBB4B [azurophil granule lumen]

TUBB [extracellular region]

TUBB3 [cytosol]

TUBB1 [cytosol]

TUBB4B [cytosol]

TUBB6 [cytosol]

Inferred From

Tubulin beta-8 chain-like protein [cytosol] (Homo sapiens)

TUBB4A [cytosol] (Homo sapiens)

TUBB8 [cytosol] (Homo sapiens)

Cross References

RefSeq

XP_001347369.1