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GTF2H4 [nucleoplasm]
Stable Identifier
R-PFA-65918
Type
Protein [EntityWithAccessionedSequence]
Species
Plasmodium falciparum
Compartment
nucleoplasm
Synonyms
Q8I4Y8
Locations in the PathwayBrowser
Expand all
DNA Repair (Plasmodium falciparum)
Nucleotide Excision Repair (Plasmodium falciparum)
Global Genome Nucleotide Excision Repair (GG-NER) (Plasmodium falciparum)
Dual Incision in GG-NER (Plasmodium falciparum)
5'- incision of DNA by ERCC1:ERCC4 in GG-NER (Plasmodium falciparum)
GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Plasmodium falciparum)
TFIIH Core [nucleoplasm] (Plasmodium falciparum)
GTF2H4 [nucleoplasm] (Plasmodium falciparum)
GG-NER incision complex:Open bubble dsDNA [nucleoplasm] (Plasmodium falciparum)
GG-NER pre-incision complex:Open bubble-dsDNA [nucleoplasm] (Plasmodium falciparum)
Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] (Plasmodium falciparum)
TFIIH Core [nucleoplasm] (Plasmodium falciparum)
GTF2H4 [nucleoplasm] (Plasmodium falciparum)
DNA polymerases delta, epsilon or kappa bind the GG-NER site (Plasmodium falciparum)
GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] (Plasmodium falciparum)
TFIIH Core [nucleoplasm] (Plasmodium falciparum)
GTF2H4 [nucleoplasm] (Plasmodium falciparum)
GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Plasmodium falciparum)
TFIIH Core [nucleoplasm] (Plasmodium falciparum)
GTF2H4 [nucleoplasm] (Plasmodium falciparum)
Formation of Incision Complex in GG-NER (Plasmodium falciparum)
ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA (Plasmodium falciparum)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Plasmodium falciparum)
Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2 [nucleoplasm] (Plasmodium falciparum)
TFIIH Core [nucleoplasm] (Plasmodium falciparum)
GTF2H4 [nucleoplasm] (Plasmodium falciparum)
Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] (Plasmodium falciparum)
TFIIH Core [nucleoplasm] (Plasmodium falciparum)
GTF2H4 [nucleoplasm] (Plasmodium falciparum)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Plasmodium falciparum)
Dual incision in TC-NER (Plasmodium falciparum)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Plasmodium falciparum)
TC-NER incision complex [nucleoplasm] (Plasmodium falciparum)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Plasmodium falciparum)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Plasmodium falciparum)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Plasmodium falciparum)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Plasmodium falciparum)
Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Plasmodium falciparum)
TFIIH [nucleoplasm] (Plasmodium falciparum)
GTF2H4 [nucleoplasm] (Plasmodium falciparum)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Plasmodium falciparum)
TFIIH [nucleoplasm] (Plasmodium falciparum)
GTF2H4 [nucleoplasm] (Plasmodium falciparum)
DNA polymerases delta, epsilon or kappa bind the TC-NER site (Plasmodium falciparum)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Plasmodium falciparum)
TFIIH [nucleoplasm] (Plasmodium falciparum)
GTF2H4 [nucleoplasm] (Plasmodium falciparum)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Plasmodium falciparum)
TFIIH [nucleoplasm] (Plasmodium falciparum)
GTF2H4 [nucleoplasm] (Plasmodium falciparum)
Formation of TC-NER Pre-Incision Complex (Plasmodium falciparum)
Active RNA Pol II complex transcribes lesion-containing DNA template (Plasmodium falciparum)
Damaged dsDNA with open transcription bubble:Hyperphosphorylated RNA Pol II:TFIIH [nucleoplasm] (Plasmodium falciparum)
TFIIH [nucleoplasm] (Plasmodium falciparum)
GTF2H4 [nucleoplasm] (Plasmodium falciparum)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Plasmodium falciparum)
TFIIH [nucleoplasm] (Plasmodium falciparum)
GTF2H4 [nucleoplasm] (Plasmodium falciparum)
ERCC8:DDB1:CUL4:RBX1 ubiquitinates ERCC6 and RNA Pol II (Plasmodium falciparum)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Plasmodium falciparum)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6 [nucleoplasm] (Plasmodium falciparum)
Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Plasmodium falciparum)
TFIIH [nucleoplasm] (Plasmodium falciparum)
GTF2H4 [nucleoplasm] (Plasmodium falciparum)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] (Plasmodium falciparum)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6 [nucleoplasm] (Plasmodium falciparum)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH [nucleoplasm] (Plasmodium falciparum)
TFIIH [nucleoplasm] (Plasmodium falciparum)
GTF2H4 [nucleoplasm] (Plasmodium falciparum)
Gap-filling DNA repair synthesis and ligation in TC-NER (Plasmodium falciparum)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Plasmodium falciparum)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Plasmodium falciparum)
TFIIH [nucleoplasm] (Plasmodium falciparum)
GTF2H4 [nucleoplasm] (Plasmodium falciparum)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Plasmodium falciparum)
TFIIH [nucleoplasm] (Plasmodium falciparum)
GTF2H4 [nucleoplasm] (Plasmodium falciparum)
Gene expression (Transcription) (Plasmodium falciparum)
RNA Polymerase II Transcription (Plasmodium falciparum)
RNA Pol II CTD phosphorylation and interaction with CE (Plasmodium falciparum)
Activation of GT (Plasmodium falciparum)
RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Plasmodium falciparum)
TFIIH [nucleoplasm] (Plasmodium falciparum)
GTF2H4 [nucleoplasm] (Plasmodium falciparum)
Extrusion of 5'-end of 30 nt long transcript through the pore in Pol II complex (Plasmodium falciparum)
Pol II transcription complex containing extruded transcript to +30 [nucleoplasm] (Plasmodium falciparum)
TFIIH [nucleoplasm] (Plasmodium falciparum)
GTF2H4 [nucleoplasm] (Plasmodium falciparum)
Phosphorylation (Ser5) of RNA pol II CTD (Plasmodium falciparum)
Pol II transcription complex containing extruded transcript to +30 [nucleoplasm] (Plasmodium falciparum)
TFIIH [nucleoplasm] (Plasmodium falciparum)
GTF2H4 [nucleoplasm] (Plasmodium falciparum)
Pol II transcription complex with (ser5) phosphorylated CTD containing extruded transcript to +30 [nucleoplasm] (Plasmodium falciparum)
TFIIH [nucleoplasm] (Plasmodium falciparum)
GTF2H4 [nucleoplasm] (Plasmodium falciparum)
SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Plasmodium falciparum)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Plasmodium falciparum)
TFIIH [nucleoplasm] (Plasmodium falciparum)
GTF2H4 [nucleoplasm] (Plasmodium falciparum)
RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Plasmodium falciparum)
TFIIH [nucleoplasm] (Plasmodium falciparum)
GTF2H4 [nucleoplasm] (Plasmodium falciparum)
RNA Polymerase II Transcription Initiation And Promoter Clearance (Plasmodium falciparum)
RNA Polymerase II Promoter Escape (Plasmodium falciparum)
Addition of nucleotides 10 and 11 on the growing transcript: Third Transition (Plasmodium falciparum)
pol II transcription complex containing 11 nucleotide long transcript [nucleoplasm] (Plasmodium falciparum)
TFIIH [nucleoplasm] (Plasmodium falciparum)
GTF2H4 [nucleoplasm] (Plasmodium falciparum)
pol II transcription complex containing 9 nucleotide long transcript [nucleoplasm] (Plasmodium falciparum)
TFIIH [nucleoplasm] (Plasmodium falciparum)
GTF2H4 [nucleoplasm] (Plasmodium falciparum)
Addition of nucleotides between position +11 and +30 (Plasmodium falciparum)
Pol II transcription complex containing extruded transcript to +30 [nucleoplasm] (Plasmodium falciparum)
TFIIH [nucleoplasm] (Plasmodium falciparum)
GTF2H4 [nucleoplasm] (Plasmodium falciparum)
pol II transcription complex containing 11 nucleotide long transcript [nucleoplasm] (Plasmodium falciparum)
TFIIH [nucleoplasm] (Plasmodium falciparum)
GTF2H4 [nucleoplasm] (Plasmodium falciparum)
Metabolism of RNA (Plasmodium falciparum)
mRNA Capping (Plasmodium falciparum)
Activation of GT (Plasmodium falciparum)
RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Plasmodium falciparum)
TFIIH [nucleoplasm] (Plasmodium falciparum)
GTF2H4 [nucleoplasm] (Plasmodium falciparum)
Capping complex formation (Plasmodium falciparum)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Plasmodium falciparum)
TFIIH [nucleoplasm] (Plasmodium falciparum)
GTF2H4 [nucleoplasm] (Plasmodium falciparum)
Capping complex (initial) [nucleoplasm] (Plasmodium falciparum)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Plasmodium falciparum)
TFIIH [nucleoplasm] (Plasmodium falciparum)
GTF2H4 [nucleoplasm] (Plasmodium falciparum)
Dissociation of transcript with 5'-GMP from GT (Plasmodium falciparum)
Capping complex (GpppN..) [nucleoplasm] (Plasmodium falciparum)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Plasmodium falciparum)
TFIIH [nucleoplasm] (Plasmodium falciparum)
GTF2H4 [nucleoplasm] (Plasmodium falciparum)
Capping complex (with freed 5'- GMP) [nucleoplasm] (Plasmodium falciparum)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Plasmodium falciparum)
TFIIH [nucleoplasm] (Plasmodium falciparum)
GTF2H4 [nucleoplasm] (Plasmodium falciparum)
Formation of the CE:GMP intermediate complex (Plasmodium falciparum)
Capping complex (intermediate) [nucleoplasm] (Plasmodium falciparum)
Covalent CE:GMP intermediate complex [nucleoplasm] (Plasmodium falciparum)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Plasmodium falciparum)
TFIIH [nucleoplasm] (Plasmodium falciparum)
GTF2H4 [nucleoplasm] (Plasmodium falciparum)
Capping complex (hydrolyzed) [nucleoplasm] (Plasmodium falciparum)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Plasmodium falciparum)
TFIIH [nucleoplasm] (Plasmodium falciparum)
GTF2H4 [nucleoplasm] (Plasmodium falciparum)
Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme (Plasmodium falciparum)
Capping complex (hydrolyzed) [nucleoplasm] (Plasmodium falciparum)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Plasmodium falciparum)
TFIIH [nucleoplasm] (Plasmodium falciparum)
GTF2H4 [nucleoplasm] (Plasmodium falciparum)
Capping complex (initial) [nucleoplasm] (Plasmodium falciparum)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Plasmodium falciparum)
TFIIH [nucleoplasm] (Plasmodium falciparum)
GTF2H4 [nucleoplasm] (Plasmodium falciparum)
SPT5 subunit of Pol II binds the RNA triphosphatase (RTP) (Plasmodium falciparum)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Plasmodium falciparum)
TFIIH [nucleoplasm] (Plasmodium falciparum)
GTF2H4 [nucleoplasm] (Plasmodium falciparum)
RNA Pol II with phosphorylated CTD: CE complex [nucleoplasm] (Plasmodium falciparum)
TFIIH [nucleoplasm] (Plasmodium falciparum)
GTF2H4 [nucleoplasm] (Plasmodium falciparum)
Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA (Plasmodium falciparum)
Capping complex (intermediate) [nucleoplasm] (Plasmodium falciparum)
Covalent CE:GMP intermediate complex [nucleoplasm] (Plasmodium falciparum)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Plasmodium falciparum)
TFIIH [nucleoplasm] (Plasmodium falciparum)
GTF2H4 [nucleoplasm] (Plasmodium falciparum)
Capping complex (GpppN..) [nucleoplasm] (Plasmodium falciparum)
CE:Pol II CTD:Spt5 complex [nucleoplasm] (Plasmodium falciparum)
TFIIH [nucleoplasm] (Plasmodium falciparum)
GTF2H4 [nucleoplasm] (Plasmodium falciparum)
External Reference Information
External Reference
UniProt:Q8I4Y8
Reference Genes
BioGPS Gene:811477
ENSEMBL:PF3D7_1244200
KEGG Gene (Plasmodium falciparum):PF3D7_1244200
Monarch:811477
NCBI Gene:811477
PlasmoDB:PF3D7_1244200
Reference Transcript
RefSeq:XM_001350793.1
Participates
as a component of
TFIIH Core [nucleoplasm] (Plasmodium falciparum)
TFIIH [nucleoplasm] (Plasmodium falciparum)
Inferred From
GTF2H4 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
XP_001350829.1
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