Reactome | phospho-Sh2b2 [cytosol]

phospho-Sh2b2 [cytosol]

Stable Identifier

R-RNO-112184

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

p-Y629-SH2B2, Q9Z200

Locations in the PathwayBrowser

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Signal Transduction (Rattus norvegicus)

- Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
  - Signaling by SCF-KIT (Rattus norvegicus)
    - Regulation of KIT signaling (Rattus norvegicus)
      - Phosphorylation of APS (Rattus norvegicus)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        p-APS dimer [cytosol] (Rattus norvegicus)
        
        phospho-Sh2b2 [cytosol] (Rattus norvegicus)
      - Recruitment of CBL to KIT (Rattus norvegicus)
        
        CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Rattus norvegicus)
        
        Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Rattus norvegicus)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        p-APS dimer [cytosol] (Rattus norvegicus)
        
        phospho-Sh2b2 [cytosol] (Rattus norvegicus)
        
        Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Rattus norvegicus)
        
        p-APS dimer:p-KIT complex [plasma membrane] (Rattus norvegicus)
        
        p-APS dimer [cytosol] (Rattus norvegicus)
        
        phospho-Sh2b2 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q9Z200

Gene Names

Sh2b2

Reference Genes

BioGPS Gene:114203 Sh2b2

ENSEMBL:ENSRNOG00000001425

ENSEMBL:ENSRNOG00055000280

ENSEMBL:ENSRNOG00060011903

KEGG:rno:114203 Sh2b2

Monarch:114203 Sh2b2

NCBI Gene:114203 Sh2b2

UCSC:Q9Z200 Sh2b2

Reference Transcript

Other Identifiers

10757545

114203

1368605_at

17672833

5741055

5893334

5918123

5929587

5967124

5992072

6020599

6144536

6236624

6240176

6244324

6280940

6306538

6361672

6440194

6585266

AF095576_at

A_42_P729496

A_64_P024356

GE13331

GO:0001725

GO:0001726

GO:0001922

GO:0002376

GO:0005068

GO:0005737

GO:0005829

GO:0005856

GO:0005884

GO:0005886

GO:0007010

GO:0007165

GO:0008286

GO:0019221

GO:0019222

GO:0023052

GO:0030036

GO:0030154

GO:0035556

GO:0035591

GO:0042169

GO:0043226

GO:0050776

GO:0050853

GO:0050873

GO:0060090

ILMN_1374536

PH_rn_0005037

Participates

as a component of

p-APS dimer [cytosol] (Rattus norvegicus)

Other forms of this molecule

Sh2b2 [cytosol]

Inferred From

p-Y629-SH2B2 [cytosol] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 629 (in Homo sapiens)

Coordinate

629

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_446121.1, XP_017453728.1, XP_017453727.1, XP_008767335.1

ENSEMBL

ENSRNOT00000001935, ENSRNOP00000001935

PRO

Q9Z200

RGD

69284

PDB

1RQQ, 1YVH, 1RPY

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