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CHEK1 [nucleoplasm]
Stable Identifier
R-RNO-113826
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
nucleoplasm
Synonyms
Q91ZN7
Locations in the PathwayBrowser
Expand all
Cell Cycle (Rattus norvegicus)
Cell Cycle Checkpoints (Rattus norvegicus)
G2/M Checkpoints (Rattus norvegicus)
Activation of ATR in response to replication stress (Rattus norvegicus)
Recruitment and activation of Chk1 (Rattus norvegicus)
CHEK1 [nucleoplasm] (Rattus norvegicus)
G2/M DNA damage checkpoint (Rattus norvegicus)
Recruitment and activation of Chk1 (Rattus norvegicus)
CHEK1 [nucleoplasm] (Rattus norvegicus)
DNA Repair (Rattus norvegicus)
DNA Double-Strand Break Repair (Rattus norvegicus)
Homology Directed Repair (Rattus norvegicus)
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Rattus norvegicus)
Processing of DNA double-strand break ends (Rattus norvegicus)
Activation of CHEK1 at resected DNA DSBs (Rattus norvegicus)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Rattus norvegicus)
CHEK1 [nucleoplasm] (Rattus norvegicus)
CHEK1 is recruited to resected DNA DSBs (Rattus norvegicus)
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Rattus norvegicus)
CHEK1 [nucleoplasm] (Rattus norvegicus)
CHEK1 [nucleoplasm] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:Q91ZN7
Reference Genes
BioGPS Gene:140583
ENSEMBL:ENSRNOG00000031896
ENSEMBL:ENSRNOG00000071217
ENSEMBL:ENSRNOG00000071217.1
ENSEMBL:ENSRNOG00055009175
ENSEMBL:ENSRNOG00060012193
ENSEMBL:ENSRNOG00065016588
KEGG Gene (Rattus norvegicus):140583
Monarch:140583
NCBI Gene:140583
UCSC:Q91ZN7
Reference Transcript
RefSeq:XM_008766043.1
RefSeq:NM_080400.1
RefSeq:XM_008766042.2
Other Identifiers
10916110
1387062_a_at
140583
17850971
5743778
5753726
5797227
5947504
5960887
5964461
6012187
6137001
6138195
6149664
6167249
6198329
6251914
6344066
6355854
6396448
6628688
6675234
6700100
GE1228389
GE17249
GO:0000077
GO:0000086
GO:0000228
GO:0000278
GO:0000781
GO:0000785
GO:0000794
GO:0001833
GO:0003824
GO:0004672
GO:0004674
GO:0005524
GO:0005634
GO:0005654
GO:0005657
GO:0005694
GO:0005737
GO:0005813
GO:0005815
GO:0005856
GO:0006281
GO:0006310
GO:0006325
GO:0006338
GO:0006468
GO:0006915
GO:0006974
GO:0006997
GO:0007010
GO:0007095
GO:0010468
GO:0010569
GO:0012501
GO:0016740
GO:0019904
GO:0023052
GO:0032991
GO:0035402
GO:0036211
GO:0042127
GO:0042770
GO:0043226
GO:0043231
GO:0044818
GO:0045787
GO:0045814
GO:0045839
GO:0046602
GO:0048856
GO:0071260
GO:0140014
GO:0140096
GO:1902742
PH_rn_0003033
Participates
as an input of
Recruitment and activation of Chk1 (Rattus norvegicus)
CHEK1 is recruited to resected DNA DSBs (Rattus norvegicus)
as a component of
ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm] (Rattus norvegicus)
Other forms of this molecule
CHEK1 [cytosol]
phospho-p-S317,S345-CHEK1 [nucleoplasm]
Inferred From
CHEK1 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
XP_008764265.1
,
XP_008764264.1
,
NP_536325.1
IntEnz
2.7.11.1
Ensembl
ENSRNOP00000011226
,
ENSRNOG00000071217
,
ENSRNOT00000011226
PRO
Q91ZN7
RGD
620545
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