Reactome | Ccnd1 [nucleoplasm]

Ccnd1 [nucleoplasm]

Stable Identifier

R-RNO-113832

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

nucleoplasm

Synonyms

CCND1, P39948

Locations in the PathwayBrowser

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Cell Cycle (Rattus norvegicus)

- Cell Cycle, Mitotic (Rattus norvegicus)
  - Mitotic G1 phase and G1/S transition (Rattus norvegicus)
    - G1 Phase (Rattus norvegicus)
      - Cyclin D associated events in G1 (Rattus norvegicus)
        
        CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6 (Rattus norvegicus)
        
        CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); CDK4,CDK6:CCND; (CDK4,CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Rattus norvegicus)
        
        CDK4,CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Rattus norvegicus)
        
        CDK4/6:CCND [nucleoplasm] (Rattus norvegicus)
        
        Cyclin D [nucleoplasm] (Rattus norvegicus)
        
        Ccnd1 [nucleoplasm] (Rattus norvegicus)
        
        CDK4:CCND [nucleoplasm] (Rattus norvegicus)
        
        CDK4:CCND1 [nucleoplasm] (Rattus norvegicus)
        
        Ccnd1 [nucleoplasm] (Rattus norvegicus)
        
        CDK6:CCND [nucleoplasm] (Rattus norvegicus)
        
        Cyclin D1:Cdk6 [nucleoplasm] (Rattus norvegicus)
        
        Ccnd1 [nucleoplasm] (Rattus norvegicus)
        
        Cyclin D:CDK4,CDK6:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Rattus norvegicus)
        
        Cyclin D [nucleoplasm] (Rattus norvegicus)
        
        Ccnd1 [nucleoplasm] (Rattus norvegicus)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Rattus norvegicus)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Rattus norvegicus)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Rattus norvegicus)
        
        Cyclin D [nucleoplasm] (Rattus norvegicus)
        
        Ccnd1 [nucleoplasm] (Rattus norvegicus)
        
        p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Rattus norvegicus)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Rattus norvegicus)
        
        Cyclin D [nucleoplasm] (Rattus norvegicus)
        
        Ccnd1 [nucleoplasm] (Rattus norvegicus)
        
        p-T172-CDK4:CCND [nucleoplasm] (Rattus norvegicus)
        
        p-T172-CDK4:CCND1 [nucleoplasm] (Rattus norvegicus)
        
        Ccnd1 [nucleoplasm] (Rattus norvegicus)
        
        p-T177-CDK6:CCND [nucleoplasm] (Rattus norvegicus)
        
        p-T177-CDK6:CCND1 [nucleoplasm] (Rattus norvegicus)
        
        Ccnd1 [nucleoplasm] (Rattus norvegicus)
        
        Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex (Rattus norvegicus)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Rattus norvegicus)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Rattus norvegicus)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Rattus norvegicus)
        
        Cyclin D [nucleoplasm] (Rattus norvegicus)
        
        Ccnd1 [nucleoplasm] (Rattus norvegicus)
        
        p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Rattus norvegicus)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Rattus norvegicus)
        
        Cyclin D [nucleoplasm] (Rattus norvegicus)
        
        Ccnd1 [nucleoplasm] (Rattus norvegicus)
        
        p-T172-CDK4:CCND [nucleoplasm] (Rattus norvegicus)
        
        p-T172-CDK4:CCND1 [nucleoplasm] (Rattus norvegicus)
        
        Ccnd1 [nucleoplasm] (Rattus norvegicus)
        
        p-T177-CDK6:CCND [nucleoplasm] (Rattus norvegicus)
        
        p-T177-CDK6:CCND1 [nucleoplasm] (Rattus norvegicus)
        
        Ccnd1 [nucleoplasm] (Rattus norvegicus)
        
        Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes (Rattus norvegicus)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Rattus norvegicus)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Rattus norvegicus)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Rattus norvegicus)
        
        Cyclin D [nucleoplasm] (Rattus norvegicus)
        
        Ccnd1 [nucleoplasm] (Rattus norvegicus)
        
        p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Rattus norvegicus)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Rattus norvegicus)
        
        Cyclin D [nucleoplasm] (Rattus norvegicus)
        
        Ccnd1 [nucleoplasm] (Rattus norvegicus)
        
        p-T172-CDK4:CCND [nucleoplasm] (Rattus norvegicus)
        
        p-T172-CDK4:CCND1 [nucleoplasm] (Rattus norvegicus)
        
        Ccnd1 [nucleoplasm] (Rattus norvegicus)
        
        p-T177-CDK6:CCND [nucleoplasm] (Rattus norvegicus)
        
        p-T177-CDK6:CCND1 [nucleoplasm] (Rattus norvegicus)
        
        Ccnd1 [nucleoplasm] (Rattus norvegicus)
        
        p-T172-CDK4:CCND:CDK4 inhibitors [nucleoplasm] (Rattus norvegicus)
        
        p-T172-CDK4:CCND1:CDK4 inhibitors (CCND1) [nucleoplasm] (Rattus norvegicus)
        
        p-T172-CDK4:CCND1 [nucleoplasm] (Rattus norvegicus)
        
        Ccnd1 [nucleoplasm] (Rattus norvegicus)
        
        p-T177-CDK6:CCND:CDK6 inhibitors [nucleoplasm] (Rattus norvegicus)
        
        p-T177-CDK6:CCND1:CDK6 inhibitors (CCND1) [nucleoplasm] (Rattus norvegicus)
        
        p-T177-CDK6:CCND1 [nucleoplasm] (Rattus norvegicus)
        
        Ccnd1 [nucleoplasm] (Rattus norvegicus)
        
        Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex (Rattus norvegicus)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Rattus norvegicus)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Rattus norvegicus)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Rattus norvegicus)
        
        Cyclin D [nucleoplasm] (Rattus norvegicus)
        
        Ccnd1 [nucleoplasm] (Rattus norvegicus)
        
        p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Rattus norvegicus)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Rattus norvegicus)
        
        Cyclin D [nucleoplasm] (Rattus norvegicus)
        
        Ccnd1 [nucleoplasm] (Rattus norvegicus)
        
        p-T172-CDK4:CCND [nucleoplasm] (Rattus norvegicus)
        
        p-T172-CDK4:CCND1 [nucleoplasm] (Rattus norvegicus)
        
        Ccnd1 [nucleoplasm] (Rattus norvegicus)
        
        p-T177-CDK6:CCND [nucleoplasm] (Rattus norvegicus)
        
        p-T177-CDK6:CCND1 [nucleoplasm] (Rattus norvegicus)
        
        Ccnd1 [nucleoplasm] (Rattus norvegicus)
        
        Drug-mediated inhibition of CDK4/CDK6 activity (Rattus norvegicus)
        
        CDK4 inhibitors bind CDK4 (Rattus norvegicus)
        
        p-T172-CDK4:CCND [nucleoplasm] (Rattus norvegicus)
        
        p-T172-CDK4:CCND1 [nucleoplasm] (Rattus norvegicus)
        
        Ccnd1 [nucleoplasm] (Rattus norvegicus)
        
        p-T172-CDK4:CCND:CDK4 inhibitors [nucleoplasm] (Rattus norvegicus)
        
        p-T172-CDK4:CCND1:CDK4 inhibitors (CCND1) [nucleoplasm] (Rattus norvegicus)
        
        p-T172-CDK4:CCND1 [nucleoplasm] (Rattus norvegicus)
        
        Ccnd1 [nucleoplasm] (Rattus norvegicus)
        
        CDK6 inhibitors bind CDK6 (Rattus norvegicus)
        
        p-T177-CDK6:CCND [nucleoplasm] (Rattus norvegicus)
        
        p-T177-CDK6:CCND1 [nucleoplasm] (Rattus norvegicus)
        
        Ccnd1 [nucleoplasm] (Rattus norvegicus)
        
        p-T177-CDK6:CCND:CDK6 inhibitors [nucleoplasm] (Rattus norvegicus)
        
        p-T177-CDK6:CCND1:CDK6 inhibitors (CCND1) [nucleoplasm] (Rattus norvegicus)
        
        p-T177-CDK6:CCND1 [nucleoplasm] (Rattus norvegicus)
        
        Ccnd1 [nucleoplasm] (Rattus norvegicus)
        
        RB1 binds and inhibits E2F1/2/3:DP1/2 complexes (Rattus norvegicus)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); p-T172-CDK4,p-T177-CDK6:CCND; (p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Rattus norvegicus)
        
        p-T172-CDK4,p-T177-CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Rattus norvegicus)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Rattus norvegicus)
        
        Cyclin D [nucleoplasm] (Rattus norvegicus)
        
        Ccnd1 [nucleoplasm] (Rattus norvegicus)
        
        p-T172-CDK4,p-T177-CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Rattus norvegicus)
        
        p-T172-CDK4,p-T177-CDK6:CCND [nucleoplasm] (Rattus norvegicus)
        
        Cyclin D [nucleoplasm] (Rattus norvegicus)
        
        Ccnd1 [nucleoplasm] (Rattus norvegicus)
        
        p-T172-CDK4:CCND [nucleoplasm] (Rattus norvegicus)
        
        p-T172-CDK4:CCND1 [nucleoplasm] (Rattus norvegicus)
        
        Ccnd1 [nucleoplasm] (Rattus norvegicus)
        
        p-T177-CDK6:CCND [nucleoplasm] (Rattus norvegicus)
        
        p-T177-CDK6:CCND1 [nucleoplasm] (Rattus norvegicus)
        
        Ccnd1 [nucleoplasm] (Rattus norvegicus)
        
        Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus (Rattus norvegicus)
        
        CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); CDK4,CDK6:CCND; (CDK4,CDK6:CCND:p-Y88-CDKN1B) [nucleoplasm] (Rattus norvegicus)
        
        CDK4,CDK6:CCND:p-Y88-CDKN1B [nucleoplasm] (Rattus norvegicus)
        
        CDK4/6:CCND [nucleoplasm] (Rattus norvegicus)
        
        Cyclin D [nucleoplasm] (Rattus norvegicus)
        
        Ccnd1 [nucleoplasm] (Rattus norvegicus)
        
        CDK4:CCND [nucleoplasm] (Rattus norvegicus)
        
        CDK4:CCND1 [nucleoplasm] (Rattus norvegicus)
        
        Ccnd1 [nucleoplasm] (Rattus norvegicus)
        
        CDK6:CCND [nucleoplasm] (Rattus norvegicus)
        
        Cyclin D1:Cdk6 [nucleoplasm] (Rattus norvegicus)
        
        Ccnd1 [nucleoplasm] (Rattus norvegicus)
        
        Cyclin D:CDK4,CDK6:CDKN1A,CDKN1B,(CDKN1C) [nucleoplasm] (Rattus norvegicus)
        
        Cyclin D [nucleoplasm] (Rattus norvegicus)
        
        Ccnd1 [nucleoplasm] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P39948

Gene Names

Ccnd1

Reference Genes

BioGPS Gene:58919 Ccnd1

ENSEMBL:ENSRNOG00000020918

ENSEMBL:ENSRNOG00000020918.6 Ccnd1

ENSEMBL:ENSRNOG00055020798

ENSEMBL:ENSRNOG00060031868

ENSEMBL:ENSRNOG00065029228

KEGG Gene (Rattus norvegicus):58919 Ccnd1

Monarch:58919 Ccnd1

NCBI Gene:58919 Ccnd1

UCSC:P39948 Ccnd1

Reference Transcript

RefSeq:NM_171992.4 Ccnd1

Other Identifiers

10727260

1371150_at

1371643_at

17638903

5619063

5637897

5786446

5797996

58919

5926198

6078295

6098388

6361635

6638932

6645503

A_44_P411505

A_64_P155393

D14014_at

D14014_g_at

GE1299175

ILMN_1350372

PH_rn_0016000

X75207_s_at

rc_AI029058_s_at

Participates

as a component of

as a candidate of

CCND3,(CCND1,CCND2) [nucleoplasm] (Rattus norvegicus)

as an input of

CCND1 binds RUNX3 and displaces EP300 (Rattus norvegicus)

as a member of

Cyclin D [nucleoplasm] (Rattus norvegicus)

Other forms of this molecule

phospho-Ccnd1 [cytosol]

phospho-Ccnd1 [nucleoplasm]

Ccnd1 [cytosol]

Inferred From

CCND1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_741989.3

Ensembl

ENSRNOG00000020918, ENSRNOP00000083271, ENSRNOT00000108193

PRO

P39948

RGD

68384

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