Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
VCP [cytosol]
Stable Identifier
R-RNO-1181251
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
P46462
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Rattus norvegicus)
Cellular responses to stress (Rattus norvegicus)
Cellular response to chemical stress (Rattus norvegicus)
KEAP1-NFE2L2 pathway (Rattus norvegicus)
UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Rattus norvegicus)
NPLOC4:UBF1:VCP hexamer [cytosol] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
VCP [cytosol] (Rattus norvegicus)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
VCP [cytosol] (Rattus norvegicus)
UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Rattus norvegicus)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
VCP [cytosol] (Rattus norvegicus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Rattus norvegicus)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
VCP [cytosol] (Rattus norvegicus)
Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Rattus norvegicus)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
VCP [cytosol] (Rattus norvegicus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Rattus norvegicus)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
VCP [cytosol] (Rattus norvegicus)
Cellular response to heat stress (Rattus norvegicus)
HSF1 activation (Rattus norvegicus)
Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates (Rattus norvegicus)
HDAC6:VCP:protein aggregates [cytosol] (Rattus norvegicus)
VCP [cytosol] (Rattus norvegicus)
HSF1:HSP90:HDAC6:VCP:PTGES3 [cytosol] (Rattus norvegicus)
VCP [cytosol] (Rattus norvegicus)
Metabolism of proteins (Rattus norvegicus)
Post-translational protein modification (Rattus norvegicus)
Asparagine N-linked glycosylation (Rattus norvegicus)
N-glycan trimming in the ER and Calnexin/Calreticulin cycle (Rattus norvegicus)
Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins (Rattus norvegicus)
Deglycosylation complex [endoplasmic reticulum membrane] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
VCP [cytosol] (Rattus norvegicus)
Deubiquitination (Rattus norvegicus)
Ovarian tumor domain proteases (Rattus norvegicus)
YOD1 binds VCP (Rattus norvegicus)
VCP [cytosol] (Rattus norvegicus)
YOD1:VCP [cytosol] (Rattus norvegicus)
VCP [cytosol] (Rattus norvegicus)
Neddylation (Rattus norvegicus)
UBXN7 binds VCP hexamer:UBF1:NPLOC4 (Rattus norvegicus)
NPLOC4:UBF1:VCP hexamer [cytosol] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
VCP [cytosol] (Rattus norvegicus)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
VCP [cytosol] (Rattus norvegicus)
UBXN7:UBF1:NPLOC4:VCP hexamer binds NFE2L2:CRL3 complex (Rattus norvegicus)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
VCP [cytosol] (Rattus norvegicus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Rattus norvegicus)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
VCP [cytosol] (Rattus norvegicus)
Ubiquitinated NFE2L2 is extracted from CRL3 complex for degradation (Rattus norvegicus)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
VCP [cytosol] (Rattus norvegicus)
ub-NFE2L2:KEAP1:NEDD8-CUL3:RBX1:UBXN7:UBF1:NPLOC4:VCP hexamer [cytosol] (Rattus norvegicus)
UBXN7:NPLOC4:UBF1:VCP hexamer [cytosol] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
VCP [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Signaling by Hedgehog (Rattus norvegicus)
Hedgehog ligand biogenesis (Rattus norvegicus)
C-terminal Hh fragments are recruited to SEL1:SYVN1 at the ER membrane (Rattus norvegicus)
C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Rattus norvegicus)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
VCP [cytosol] (Rattus norvegicus)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
VCP [cytosol] (Rattus norvegicus)
SYVN1 ubiquitinates Hh C-terminal fragments (Rattus norvegicus)
C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Rattus norvegicus)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
VCP [cytosol] (Rattus norvegicus)
ub-C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Rattus norvegicus)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
VCP [cytosol] (Rattus norvegicus)
VCP-catalyzed ATP hydrolysis promotes the translocation of Hh-C into the cytosol (Rattus norvegicus)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
VCP [cytosol] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
VCP [cytosol] (Rattus norvegicus)
ub-C-terminal Hh fragments:ERLEC/OS9:SEL1:SYVN1dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Rattus norvegicus)
SEL1:SYVN1 dimer:DERL2:VCP hexamer [endoplasmic reticulum membrane] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
VCP [cytosol] (Rattus norvegicus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Rattus norvegicus)
Signaling by Rho GTPases (Rattus norvegicus)
RHO GTPase cycle (Rattus norvegicus)
RHOH GTPase cycle (Rattus norvegicus)
RHOH binds effectors at the plasma membrane (Rattus norvegicus)
RHOH effectors [cytosol] (Rattus norvegicus)
VCP [cytosol] (Rattus norvegicus)
RHOH:GTP:RHOH effectors [plasma membrane] (Rattus norvegicus)
RHOH effectors [cytosol] (Rattus norvegicus)
VCP [cytosol] (Rattus norvegicus)
Transport of small molecules (Rattus norvegicus)
ABC-family proteins mediated transport (Rattus norvegicus)
CFTR binds components of the ERAD machinery for ubiquitination and degradation (Rattus norvegicus)
ERAD complex [endoplasmic reticulum membrane] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
VCP [cytosol] (Rattus norvegicus)
misfolded CFTR:ERAD complex [endoplasmic reticulum membrane] (Rattus norvegicus)
ERAD complex [endoplasmic reticulum membrane] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
VCP [cytosol] (Rattus norvegicus)
RNF5 and RNF185 ubiquitinate misfolded CFTR (Rattus norvegicus)
Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] (Rattus norvegicus)
ERAD complex [endoplasmic reticulum membrane] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
VCP [cytosol] (Rattus norvegicus)
misfolded CFTR:ERAD complex [endoplasmic reticulum membrane] (Rattus norvegicus)
ERAD complex [endoplasmic reticulum membrane] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
VCP [cytosol] (Rattus norvegicus)
VCP-catalyzed ATP hydrolysis promotes the translocation of misfolded CFTR into the cytosol (Rattus norvegicus)
ERAD complex [endoplasmic reticulum membrane] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
VCP [cytosol] (Rattus norvegicus)
Ub-misfolded nascent CFTR:ERAD complex [endoplasmic reticulum membrane] (Rattus norvegicus)
ERAD complex [endoplasmic reticulum membrane] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
VCP [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:P46462
Reference Genes
BioGPS Gene:116643
ENSEMBL:ENSRNOG00000034242
KEGG:rno:116643
Monarch:116643
NCBI Gene:116643
UCSC:P46462
Reference Transcript
RefSeq:NM_053864.2
Other Identifiers
10700160
10700258
10700270
10700279
10700299
10700457
10700514
10700607
10700736
10700806
10700866
10700880
10700938
10700959
10701133
10701153
10701163
10701198
10701312
10701492
10876224
116643
1367455_at
17806694
5624838
5639507
5725976
5734477
5761907
5790228
5793763
5811995
5821706
5921248
5996316
5996843
6063714
6086785
6225679
6251661
6265240
6354288
6424944
6642475
6643191
A_44_P156433
GE1154530
GO:0000502
GO:0003824
GO:0005524
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005783
GO:0005789
GO:0005811
GO:0005829
GO:0006091
GO:0006281
GO:0006302
GO:0006511
GO:0006734
GO:0006886
GO:0006914
GO:0006974
GO:0010494
GO:0010498
GO:0010918
GO:0016192
GO:0016236
GO:0016567
GO:0016787
GO:0016887
GO:0019079
GO:0019903
GO:0019904
GO:0019985
GO:0023052
GO:0030163
GO:0030433
GO:0030970
GO:0031334
GO:0031593
GO:0031625
GO:0032436
GO:0032510
GO:0032991
GO:0034098
GO:0034605
GO:0035331
GO:0035617
GO:0035800
GO:0035861
GO:0036211
GO:0036435
GO:0036503
GO:0036513
GO:0042288
GO:0042802
GO:0043161
GO:0043226
GO:0043531
GO:0044389
GO:0045202
GO:0045732
GO:0045879
GO:0046034
GO:0048471
GO:0055086
GO:0060090
GO:0061857
GO:0065003
GO:0070842
GO:0071218
GO:0072389
GO:0090263
GO:0097352
GO:0098772
GO:0106300
GO:0120186
GO:0140036
GO:0140455
GO:0140657
GO:1901135
GO:1901224
GO:1903006
GO:1903715
GO:1903843
GO:1903862
GO:1904288
GO:1904949
GO:1905634
GO:1990381
GO:1990730
GO:2001171
ILMN_1363637
PH_rn_0004040
U11760_at
rc_AI044341_s_at
Participates
as a candidate of
RHOH effectors [cytosol] (Rattus norvegicus)
as an input of
YOD1 binds VCP (Rattus norvegicus)
as a component of
YOD1:VCP [cytosol] (Rattus norvegicus)
HDAC6:VCP:protein aggregates [cytosol] (Rattus norvegicus)
HSF1:HSP90:HDAC6:VCP:PTGES3 [cytosol] (Rattus norvegicus)
VCP hexamer [cytosol] (Rattus norvegicus)
Other forms of this molecule
Me3K315-VCP [cytosol]
VCP [nucleoplasm]
VCP [azurophil granule lumen]
VCP [secretory granule lumen]
VCP [extracellular region]
VCP [ficolin-1-rich granule lumen]
Inferred From
VCP [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_446316.1
ENSEMBL
ENSRNOT00000046102
,
ENSRNOP00000040121
,
ENSRNOG00000034242
IntEnz
3.6.4.6
PRO
P46462
GlyGen
P46462
RGD
621595
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O35987
1
Nsfl1c [cytosol]
(R-RNO-9714673)
0.868
12
UniProt:Q9ES54
2
Nploc4 [nucleoplasm]
(R-RNO-5654987)
Nploc4 [cytosol]
(R-RNO-9755492)
0.558
3
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text