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Prlr binds Shp2
Stable Identifier
R-RNO-1369092
Type
Reaction [binding]
Species
Rattus norvegicus
Compartment
cytosol
,
plasma membrane
ReviewStatus
5/5
General
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SBGN
Prlr can bind the protein-tyrosine Phosphatase Shp2, (Ptpn11) via its C-terminal SH2 Domain. This binding does not occur when tyrosine 599 is mutated to alanine (Ali & Ali 2000).
Literature References
PubMed ID
Title
Journal
Year
10991949
Recruitment of the protein-tyrosine phosphatase SHP-2 to the C-terminal tyrosine of the prolactin receptor and to the adaptor protein Gab2
Ali, S
,
Ali, S
J Biol Chem
2000
Participants
Input
Prlr ligands:p(Y599)-Prlr:p(Y1007)-Jak2 dimer [plasma membrane]
(Rattus norvegicus)
Ptpn11 [cytosol]
(Rattus norvegicus)
Output
Prlr ligands:p(Y599)-Prlr:p(Y1007)-Jak2 dimer:Shp2 [plasma membrane]
(Rattus norvegicus)
Orthologous Events
PRLR binds SHP2 (PTPN11) (Homo sapiens)
Authored
Jupe, S (2011-06-13)
Reviewed
Goffin, V (2011-11-08)
Created
Jupe, S (2011-07-04)
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