Reactome | Rbm8a [cytosol]

Rbm8a [cytosol]

Stable Identifier

R-RNO-162462

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

RBM8A, Q27W01

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Rattus norvegicus)

- Nonsense-Mediated Decay (NMD) (Rattus norvegicus)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Rattus norvegicus)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Rattus norvegicus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Rattus norvegicus)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Rattus norvegicus)
        
        Magoh-Y14 complex [cytosol] (Rattus norvegicus)
        
        Rbm8a [cytosol] (Rattus norvegicus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Rattus norvegicus)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Rattus norvegicus)
        
        Magoh-Y14 complex [cytosol] (Rattus norvegicus)
        
        Rbm8a [cytosol] (Rattus norvegicus)
    - SMG6 hydrolyzes mRNA with premature termination codon (Rattus norvegicus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Rattus norvegicus)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Rattus norvegicus)
        
        Magoh-Y14 complex [cytosol] (Rattus norvegicus)
        
        Rbm8a [cytosol] (Rattus norvegicus)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Rattus norvegicus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Rattus norvegicus)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Rattus norvegicus)
        
        Magoh-Y14 complex [cytosol] (Rattus norvegicus)
        
        Rbm8a [cytosol] (Rattus norvegicus)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Rattus norvegicus)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Rattus norvegicus)
        
        Magoh-Y14 complex [cytosol] (Rattus norvegicus)
        
        Rbm8a [cytosol] (Rattus norvegicus)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Rattus norvegicus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Rattus norvegicus)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Rattus norvegicus)
        
        Magoh-Y14 complex [cytosol] (Rattus norvegicus)
        
        Rbm8a [cytosol] (Rattus norvegicus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Rattus norvegicus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Rattus norvegicus)
        
        Exon Junction:UPF2:UPF3 Complex [cytosol] (Rattus norvegicus)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Rattus norvegicus)
        
        Magoh-Y14 complex [cytosol] (Rattus norvegicus)
        
        Rbm8a [cytosol] (Rattus norvegicus)
- Processing of Capped Intron-Containing Pre-mRNA (Rattus norvegicus)
  - Transport of Mature Transcript to Cytoplasm (Rattus norvegicus)
    - Transport of Mature mRNA derived from an Intron-Containing Transcript (Rattus norvegicus)
      - Transport of the export-competent mRNP complex through the NPC (Rattus norvegicus)
        
        NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Rattus norvegicus)
        
        EJC [cytosol] (Rattus norvegicus)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Rattus norvegicus)
        
        Magoh-Y14 complex [cytosol] (Rattus norvegicus)
        
        Rbm8a [cytosol] (Rattus norvegicus)
      - mRNP complex dissociates from cytosolic face of NPC (Rattus norvegicus)
        
        NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol] (Rattus norvegicus)
        
        EJC [cytosol] (Rattus norvegicus)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Rattus norvegicus)
        
        Magoh-Y14 complex [cytosol] (Rattus norvegicus)
        
        Rbm8a [cytosol] (Rattus norvegicus)
        
        mRNA:CBC:EJC:POLDIP3 [cytosol] (Rattus norvegicus)
        
        EJC [cytosol] (Rattus norvegicus)
        
        Core Exon Junction Complex (Core EJC) [cytosol] (Rattus norvegicus)
        
        Magoh-Y14 complex [cytosol] (Rattus norvegicus)
        
        Rbm8a [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:Q27W01

Gene Names

Rbm8a

Reference Genes

BioGPS Gene:295284 Rbm8a

ENSEMBL:ENSRNOG00000021215

ENSEMBL:ENSRNOG00000021215.8 Rbm8a

ENSEMBL:ENSRNOG00055032492

ENSEMBL:ENSRNOG00060012608

ENSEMBL:ENSRNOG00065032176

KEGG Gene (Rattus norvegicus):295284 Rbm8a

Monarch:295284 Rbm8a

NCBI Gene:295284 Rbm8a

UCSC:Q27W01 Rbm8a

Reference Transcript

RefSeq:NM_001271138.1 Rbm8a

Other Identifiers

10817573

1372829_at

1384751_at

17741026

295284

5663627

5690270

5706882

5775675

5881166

5987410

6044750

6273126

6724290

A_42_P685418

A_64_P134089

GE17756

GO:0000184

GO:0000381

GO:0000398

GO:0003676

GO:0003723

GO:0003729

GO:0005634

GO:0005654

GO:0005737

GO:0006396

GO:0016071

GO:0016607

GO:0035145

GO:0043226

GO:0050684

GO:0071006

GO:0071013

GO:1990501

GO:2000622

ILMN_1361722

PH_rn_0001272

PH_rn_0023056

rc_AA996689_at

rc_AI044836_at

rc_AI145282_at

Participates

as a component of

Magoh-Y14 complex [cytosol] (Rattus norvegicus)

Other forms of this molecule

Rbm8a [nucleoplasm]

Inferred From

RBM8A [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001258067.1

Ensembl

ENSRNOG00000021215, ENSRNOT00000028807, ENSRNOP00000028807

PRO

Q27W01

RGD

1310099

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