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PAK1 [cytosol]
Stable Identifier
R-RNO-162629
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
P35465
Locations in the PathwayBrowser
Expand all
Developmental Biology (Rattus norvegicus)
Nervous system development (Rattus norvegicus)
Axon guidance (Rattus norvegicus)
EPH-Ephrin signaling (Rattus norvegicus)
EPHB-mediated forward signaling (Rattus norvegicus)
PAK1 binds RAC1:GTP (Rattus norvegicus)
PAK1 dimer [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
Ephrin signaling (Rattus norvegicus)
PAK binds RAC and bPIX (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Rattus norvegicus)
PAK1/3, 2 [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
PAK1/3, 2 [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
PAKs autophosphorylate (Rattus norvegicus)
EPHBs:p-3Y-EFNBs:SRC,FYN:GRB4:p-GIT1:ARHGEF7:RAC1:GTP:PAK1,3 [plasma membrane] (Rattus norvegicus)
PAK1/3, 2 [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
PAK1/3, 2 [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
L1CAM interactions (Rattus norvegicus)
Signal transduction by L1 (Rattus norvegicus)
Interaction of PAK1 with Rac1-GTP (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
PAK1 dimer [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
Semaphorin interactions (Rattus norvegicus)
Sema3A PAK dependent Axon repulsion (Rattus norvegicus)
Activation of PAK by Rac1 (Rattus norvegicus)
PAK1,2,3 [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
PAK1,2,3 dimer [cytosol] (Rattus norvegicus)
PAK1 dimer [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
Sema3A:Nrp-1:PlexinA:Rac1-GTP:PAK [plasma membrane] (Rattus norvegicus)
PAK1,2,3 [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
Autophosphorylation of PAK (Rattus norvegicus)
PAK1,2,3 [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
Sema3A:Nrp-1:PlexinA:Rac1-GTP:PAK [plasma membrane] (Rattus norvegicus)
PAK1,2,3 [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
Regulation of T cell activation by CD28 family (Rattus norvegicus)
Co-stimulation by CD28 (Rattus norvegicus)
CD28 dependent Vav1 pathway (Rattus norvegicus)
Activation of PAKs by RAC1 and CDC42 (Rattus norvegicus)
PAK1,2,3 [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
PAK1,2,3 dimer [cytosol] (Rattus norvegicus)
PAK1 dimer [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
PAK1,2,3:CDC42:GTP, RAC1:GTP [plasma membrane] (Rattus norvegicus)
PAK1,2,3 [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
TCR signaling (Rattus norvegicus)
Generation of second messenger molecules (Rattus norvegicus)
NCK binds PAK (Rattus norvegicus)
PAK1,2,3 [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
p-SLP-76:NCK:PAK [cytosol] (Rattus norvegicus)
PAK1,2,3 [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
C-type lectin receptors (CLRs) (Rattus norvegicus)
CD209 (DC-SIGN) signaling (Rattus norvegicus)
PAK phosphorylates p21 RAF1 on S338 (Rattus norvegicus)
PAK1,2,3 [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
Fc epsilon receptor (FCERI) signaling (Rattus norvegicus)
FCERI mediated MAPK activation (Rattus norvegicus)
Autophosphorylation of PAK (Rattus norvegicus)
PAK dimer [cytosol] (Rattus norvegicus)
PAK1 dimer [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Rattus norvegicus)
PAK dimer [cytosol] (Rattus norvegicus)
PAK1 dimer [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
Recruitment of PAK to the membrane by binding active RAC1 (Rattus norvegicus)
PAK dimer [cytosol] (Rattus norvegicus)
PAK1 dimer [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Rattus norvegicus)
PAK dimer [cytosol] (Rattus norvegicus)
PAK1 dimer [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
Fcgamma receptor (FCGR) dependent phagocytosis (Rattus norvegicus)
Regulation of actin dynamics for phagocytic cup formation (Rattus norvegicus)
Autophosphorylation of PAK1 (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
RAC1:GTP,CDC42:GTP:PAK1 [plasma membrane] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
RAC1 and CDC42 activate PAK1 (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
PAK1 dimer [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
RAC1:GTP,CDC42:GTP:PAK1 [plasma membrane] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
MAPK family signaling cascades (Rattus norvegicus)
MAPK6/MAPK4 signaling (Rattus norvegicus)
Activation of PAKs by RAC1 and CDC42 (Rattus norvegicus)
PAK1,2,3 [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
PAK1,2,3 dimer [cytosol] (Rattus norvegicus)
PAK1 dimer [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
PAK1,2,3:CDC42:GTP, RAC1:GTP [plasma membrane] (Rattus norvegicus)
PAK1,2,3 [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
Autophosphorylation of PAK1,2,3 (Rattus norvegicus)
CDC42:GTP,RAC1:GTP:PAK1,PAK2,PAK3 [plasma membrane] (Rattus norvegicus)
RAC1:GTP,CDC42:GTP:PAK1 [plasma membrane] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
Signaling by GPCR (Rattus norvegicus)
GPCR downstream signalling (Rattus norvegicus)
G-protein beta:gamma signalling (Rattus norvegicus)
G beta:gamma signalling through CDC42 (Rattus norvegicus)
CDC42 binds GNB/GNG:PAK1:ARHGEF6 complex (Rattus norvegicus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Rattus norvegicus)
Active PAK1:ARHGEF6 [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
G-protein beta-gamma complex:PAK1:ARHGEF6:CDC42 [plasma membrane] (Rattus norvegicus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Rattus norvegicus)
Active PAK1:ARHGEF6 [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated (Rattus norvegicus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6:Active CDC42 [plasma membrane] (Rattus norvegicus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Rattus norvegicus)
Active PAK1:ARHGEF6 [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
G-protein beta-gamma complex:PAK1:ARHGEF6:CDC42 [plasma membrane] (Rattus norvegicus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Rattus norvegicus)
Active PAK1:ARHGEF6 [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
PAK1 binds ARHGEF6 (Rattus norvegicus)
Active PAK1:ARHGEF6 [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
PAK1 in GNB/GNG:PAK1:ARHGEF6:Active CDC42 is activated (Rattus norvegicus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6:Active CDC42 [plasma membrane] (Rattus norvegicus)
G-protein beta-gamma complex:Active PAK1:ARHGEF6 [plasma membrane] (Rattus norvegicus)
Active PAK1:ARHGEF6 [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by VEGF (Rattus norvegicus)
VEGFA-VEGFR2 Pathway (Rattus norvegicus)
VEGFR2 mediated vascular permeability (Rattus norvegicus)
PAK1-3 autophosphorylates (Rattus norvegicus)
PAK1,2,3 dimer [cytosol] (Rattus norvegicus)
PAK1 dimer [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Rattus norvegicus)
PAK1,2,3 [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
PAK1-3 dimer disassociates (Rattus norvegicus)
2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Rattus norvegicus)
PAK1,2,3 dimer [cytosol] (Rattus norvegicus)
PAK1 dimer [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Rattus norvegicus)
PAK1,2,3 [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
RAC1 binds PAK1-3 (Rattus norvegicus)
2 x p-VAV family:PIP3:RAC1:GTP:PAK 1-3 [plasma membrane] (Rattus norvegicus)
PAK1,2,3 dimer [cytosol] (Rattus norvegicus)
PAK1 dimer [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
PAK1,2,3 dimer [cytosol] (Rattus norvegicus)
PAK1 dimer [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Rattus norvegicus)
Signaling by Rho GTPases (Rattus norvegicus)
RHO GTPase Effectors (Rattus norvegicus)
RHO GTPases activate PAKs (Rattus norvegicus)
Autophosphorylation of PAK1,2,3 (Rattus norvegicus)
CDC42:GTP,RAC1:GTP:PAK1,PAK2,PAK3 [plasma membrane] (Rattus norvegicus)
RAC1:GTP,CDC42:GTP:PAK1 [plasma membrane] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
NF2 binds PAK1 (Rattus norvegicus)
PAK1 dimer [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
PAK1:NF2 [plasma membrane] (Rattus norvegicus)
PAK1 dimer [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
RAC1 and CDC42 activate PAK1 (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
PAK1 dimer [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
RAC1:GTP,CDC42:GTP:PAK1 [plasma membrane] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
RHO GTPase cycle (Rattus norvegicus)
RAC1 GTPase cycle (Rattus norvegicus)
RAC1 binds effectors at the plasma membrane (Rattus norvegicus)
RAC1 effectors [cytosol] (Rattus norvegicus)
PAK1 dimer [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
RAC1:GTP:RAC1 effectors [plasma membrane] (Rattus norvegicus)
RAC1 effectors [cytosol] (Rattus norvegicus)
PAK1 dimer [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
RAC2 GTPase cycle (Rattus norvegicus)
RAC2 binds effectors at the plasma membrane (Rattus norvegicus)
RAC2 plasma membrane effectors [cytosol] (Rattus norvegicus)
PAK1 dimer [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
RAC2:GTP:RAC2 cytosolic effectors [plasma membrane] (Rattus norvegicus)
RAC2 plasma membrane effectors [cytosol] (Rattus norvegicus)
PAK1 dimer [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
RHOH GTPase cycle (Rattus norvegicus)
RHOH binds effectors at the plasma membrane (Rattus norvegicus)
RHOH effectors [cytosol] (Rattus norvegicus)
PAK1 dimer [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
RHOH:GTP:RHOH effectors [plasma membrane] (Rattus norvegicus)
RHOH effectors [cytosol] (Rattus norvegicus)
PAK1 dimer [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
RHOQ GTPase cycle (Rattus norvegicus)
RHOQ binds effectors at the plasma membrane (Rattus norvegicus)
RHOQ effectors [cytosol] (Rattus norvegicus)
PAK1 dimer [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
RHOQ:GTP:RHOQ effectors [plasma membrane] (Rattus norvegicus)
RHOQ effectors [cytosol] (Rattus norvegicus)
PAK1 dimer [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
RHOU GTPase cycle (Rattus norvegicus)
RHOU binds effectors at the plasma membrane (Rattus norvegicus)
RHOU effectors [cytosol] (Rattus norvegicus)
PAK1 dimer [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
RHOU:GTP:RHOU effectors [plasma membrane] (Rattus norvegicus)
RHOU effectors [cytosol] (Rattus norvegicus)
PAK1 dimer [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
RHOV GTPase cycle (Rattus norvegicus)
RHOV binds effectors at the plasma membrane (Rattus norvegicus)
RHOV effectors [cytosol] (Rattus norvegicus)
PAK1 dimer [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
RHOV:GTP:RHOV effectors [plasma membrane] (Rattus norvegicus)
RHOV effectors [cytosol] (Rattus norvegicus)
PAK1 dimer [cytosol] (Rattus norvegicus)
PAK1 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:P35465
Reference Genes
BioGPS Gene:29431
ENSEMBL:ENSRNOG00000029784
ENSEMBL:ENSRNOG00055030086
ENSEMBL:ENSRNOG00060002471
ENSEMBL:ENSRNOG00065021787
KEGG:rno:29431
Monarch:29431
NCBI Gene:29431
UCSC:P35465
Reference Transcript
RefSeq:NM_017198.1
RefSeq:XM_006229754.3
RefSeq:XM_006229752.2
RefSeq:XM_006229753.2
Other Identifiers
10708834
1387377_a_at
1389093_at
17618479
29431
5642567
5649965
5658177
5701319
5737745
5745498
5895419
5959129
5963907
5976163
6057005
6108713
6148164
6154627
6245055
6260182
6314038
6515772
6618640
6621099
6681329
6712296
AA851136_g_at
A_44_P325005
GE1134712
GE20413
GE21941
GO:0003824
GO:0004672
GO:0004674
GO:0005524
GO:0006468
GO:0016740
GO:0036211
GO:0140096
ILMN_1362113
PH_rn_0006367
U49953_s_at
rc_AI172085_at
rc_AI175989_at
Participates
as a member of
PAK1/3, 2 [cytosol] (Rattus norvegicus)
PAK1,2,3 [cytosol] (Rattus norvegicus)
as an output of
Interaction of PAK1 with Rac1-GTP (Rattus norvegicus)
RAC1 and CDC42 activate PAK1 (Rattus norvegicus)
as an input of
PAK1 binds ARHGEF6 (Rattus norvegicus)
as a component of
Active PAK1:ARHGEF6 [cytosol] (Rattus norvegicus)
RAC1:GTP,CDC42:GTP:PAK1 [plasma membrane] (Rattus norvegicus)
PAK1 dimer [cytosol] (Rattus norvegicus)
Other forms of this molecule
PAK1 [plasma membrane]
phospho-p-S144,T423-PAK1 [plasma membrane]
phospho-p-S144,T423-PAK1 [cytosol]
Inferred From
Active PAK1 [cytosol]
(Homo sapiens)
PAK1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
XP_006229814.1
,
XP_006229815.1
,
XP_006229816.1
,
NP_058894.1
ENSEMBL
ENSRNOT00000091952
,
ENSRNOP00000073036
IntEnz
2.7.11.1
PRO
P35465
RGD
3250
PDB
1E0A
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O55043 Arhgef7
3
Arhgef7 [cytosol]
(R-RNO-430346)
p-S516-Arhgef7 [cytosol]
(R-RNO-9619782)
Arhgef7 [cytosol]
(R-RNO-442693)
0.553
2
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