2-acylglycerol + H2O -> glycerol + fatty acid

Stable Identifier
R-RNO-163439
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
2-acylglycerol + H2O -> glycerol + fatty acid
Rat monoacylglycerol lipase (MGLL) catalyzes the hydrolysis of 2-acylglycerol to yield glycerol + fatty acid (Tornqvist and Belfrage 1976; Fredrikson et al. 1986). Localization of the enzyme to lipid particles is plausible, given its low solubility and its involvement in acylglycerol metabolism, but this localization has not been directly experimentally verified. The human reaction is inferred from the well-studied rat one.
Literature References
PubMed ID Title Journal Year
3955067 Hormone-sensitive lipase and monoacylglycerol lipase are both required for complete degradation of adipocyte triacylglycerol

Tornqvist, H, Belfrage, P, Fredrikson, G

Biochim Biophys Acta 1986
1249056 Purification and some properties of a monoacylglycerol-hydrolyzing enzyme of rat adipose tissue

Tornqvist, H, Belfrage, P

J Biol Chem 1976
Participants
Catalyst Activity

acylglycerol lipase activity of monoglyceride lipase [lipid droplet]

Orthologous Events
Authored
Created
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