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MTOR [cytosol]
Stable Identifier
R-RNO-165662
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
P42346
Locations in the PathwayBrowser
Expand all
Autophagy (Rattus norvegicus)
Macroautophagy (Rattus norvegicus)
Active MTORC1 binds the ULK1 complex (Rattus norvegicus)
Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
mTORC1 [cytosol] (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Rattus norvegicus)
Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
mTORC1 [cytosol] (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
Active MTORC1 phosphorylates ULK1 (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Rattus norvegicus)
Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
mTORC1 [cytosol] (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
MTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Rattus norvegicus)
Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
mTORC1 [cytosol] (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
MTORC1 dissociates from ULK complex (Rattus norvegicus)
MTORC1 with p-S722,S792-RPTOR:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Rattus norvegicus)
mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Rattus norvegicus)
mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Rattus norvegicus)
mTORC1 with p-S722,S792-RPTOR [cytosol] (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Rattus norvegicus)
mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Rattus norvegicus)
mTORC1 with p-S722,S792-RPTOR [cytosol] (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
Rheb in the MTORC1 complex hydrolyses GTP (Rattus norvegicus)
Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
mTORC1 [cytosol] (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Rattus norvegicus)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
mTORC1 [cytosol] (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Rattus norvegicus)
MTORC1 with p-S722,S792-RPTOR:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Rattus norvegicus)
mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Rattus norvegicus)
mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Rattus norvegicus)
mTORC1 with p-S722,S792-RPTOR [cytosol] (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
MTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Rattus norvegicus)
Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
mTORC1 [cytosol] (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
Cellular responses to stimuli (Rattus norvegicus)
Cellular responses to stress (Rattus norvegicus)
Cellular response to starvation (Rattus norvegicus)
Amino acids regulate mTORC1 (Rattus norvegicus)
RRAGA,B hydrolyzes GTP (Rattus norvegicus)
v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Rattus norvegicus)
mTORC1 [cytosol] (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Rattus norvegicus)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Rattus norvegicus)
mTORC1 [cytosol] (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
mTORC1 binds RHEB:GTP (Rattus norvegicus)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Rattus norvegicus)
mTORC1 [cytosol] (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Rattus norvegicus)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Rattus norvegicus)
mTORC1 [cytosol] (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Rattus norvegicus)
mTORC1 [cytosol] (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Rattus norvegicus)
mTORC1 [cytosol] (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
Gene expression (Transcription) (Rattus norvegicus)
RNA Polymerase II Transcription (Rattus norvegicus)
Generic Transcription Pathway (Rattus norvegicus)
Transcriptional Regulation by TP53 (Rattus norvegicus)
Regulation of TP53 Activity (Rattus norvegicus)
Regulation of TP53 Expression and Degradation (Rattus norvegicus)
Regulation of TP53 Degradation (Rattus norvegicus)
TORC2 complex phosphorylates SGK1 (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
TORC2 complex [cytosol] (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
TP53 Regulates Metabolic Genes (Rattus norvegicus)
RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Rattus norvegicus)
Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
mTORC1 [cytosol] (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Rattus norvegicus)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
mTORC1 [cytosol] (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
Costimulation by the CD28 family (Rattus norvegicus)
CD28 co-stimulation (Rattus norvegicus)
CD28 dependent PI3K/Akt signaling (Rattus norvegicus)
TORC2 (mTOR) phosphorylates AKT at S473 (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
TORC2 complex [cytosol] (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
Signal Transduction (Rattus norvegicus)
Intracellular signaling by second messengers (Rattus norvegicus)
PIP3 activates AKT signaling (Rattus norvegicus)
PTEN Regulation (Rattus norvegicus)
Regulation of PTEN gene transcription (Rattus norvegicus)
MAF1 translocates to the nucleus (Rattus norvegicus)
Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
mTORC1 [cytosol] (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
mTORC1 phosphorylates MAF1 (Rattus norvegicus)
Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
mTORC1 [cytosol] (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
TORC2 (mTOR) phosphorylates AKT at S473 (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
TORC2 complex [cytosol] (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
TORC2 complex phosphorylates SGK1 (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
TORC2 complex [cytosol] (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
MTOR signalling (Rattus norvegicus)
AKT1S1 (PRAS40) binds mTORC1 (Rattus norvegicus)
Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
mTORC1 [cytosol] (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Rattus norvegicus)
Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
mTORC1 [cytosol] (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Rattus norvegicus)
mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Rattus norvegicus)
Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
mTORC1 [cytosol] (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Rattus norvegicus)
Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
mTORC1 [cytosol] (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
Energy dependent regulation of mTOR by LKB1-AMPK (Rattus norvegicus)
AMPK phosphorylates Raptor in the mTORC1 complex (Rattus norvegicus)
Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
mTORC1 [cytosol] (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Rattus norvegicus)
mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Rattus norvegicus)
mTORC1 with p-S722,S792-RPTOR [cytosol] (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Rattus norvegicus)
Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
mTORC1 [cytosol] (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Rattus norvegicus)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
mTORC1 [cytosol] (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
Formation of active mTORC1 complex (Rattus norvegicus)
Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
mTORC1 [cytosol] (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
mTORC1 [cytosol] (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
Phosphorylated AKT1S1:mTORC1 binds YWHAB (Rattus norvegicus)
mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Rattus norvegicus)
Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
mTORC1 [cytosol] (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Rattus norvegicus)
mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Rattus norvegicus)
Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
mTORC1 [cytosol] (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Rattus norvegicus)
mTORC1 [cytosol] (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
mTORC1 [cytosol] (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
mTORC1 phosphorylates AKT1S1 (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
mTORC1:RHEB:GTP:p-S183,T246-AKT1S1:YWHAB [lysosomal membrane] (Rattus norvegicus)
mTORC1:RHEB:GTP:p-S183,T246-AKT1S1 [lysosomal membrane] (Rattus norvegicus)
Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
mTORC1 [cytosol] (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Rattus norvegicus)
mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Rattus norvegicus)
Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
mTORC1 [cytosol] (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
mTORC1-mediated signalling (Rattus norvegicus)
Phosphorylation of 4E-BP1 by activated mTORC1 (Rattus norvegicus)
Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
mTORC1 [cytosol] (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Rattus norvegicus)
Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
mTORC1 [cytosol] (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Rattus norvegicus)
mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Rattus norvegicus)
Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
mTORC1 [cytosol] (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
mTORC1 phosphorylation of RPS6KB1 (S6K) (Rattus norvegicus)
Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
mTORC1 [cytosol] (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Rattus norvegicus)
mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Rattus norvegicus)
mTORC1 with p-S722,S792-RPTOR [cytosol] (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Rattus norvegicus)
mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Rattus norvegicus)
Active mTORC1 complex [lysosomal membrane] (Rattus norvegicus)
mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Rattus norvegicus)
mTORC1 [cytosol] (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by VEGF (Rattus norvegicus)
VEGFA-VEGFR2 Pathway (Rattus norvegicus)
VEGFR2 mediated vascular permeability (Rattus norvegicus)
TORC2 (mTOR) phosphorylates AKT at S473 (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
TORC2 complex [cytosol] (Rattus norvegicus)
MTOR [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:P42346
Reference Genes
BioGPS Gene:56718
ENSEMBL:ENSRNOG00000009615
KEGG Gene (Rattus norvegicus):56718
Monarch:56718
NCBI Gene:56718
UCSC:P42346
Reference Transcript
RefSeq:NM_019906.1
Participates
as a component of
TORC2 complex [cytosol] (Rattus norvegicus)
mTORC1 [cytosol] (Rattus norvegicus)
mTORC1 with p-S722,S792-RPTOR [cytosol] (Rattus norvegicus)
Other forms of this molecule
MTOR [nucleoplasm]
Inferred From
MTOR [cytosol]
(Homo sapiens)
Cross References
ZINC - Investigational
MTOR_RAT
RefSeq
NP_063971.1
ZINC - Substances
MTOR_RAT
ZINC target
P42346
PRO
P42346
RGD
68371
ZINC - Predictions - Purchasable
MTOR_RAT
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q62622
2
Eif4ebp1 [cytosol]
(R-RNO-72580)
phospho-Eif4ebp1 [cytosol]
(R-RNO-165685)
0.623
3
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