Reactome | Ppp2ca [cytosol]

Ppp2ca [cytosol]

Stable Identifier

R-RNO-165971

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

PPP2CA, P63331

Locations in the PathwayBrowser

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Cell Cycle (Rattus norvegicus)

- Cell Cycle Checkpoints (Rattus norvegicus)
  - Mitotic Spindle Checkpoint (Rattus norvegicus)
    - Amplification of signal from the kinetochores (Rattus norvegicus)
      - Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Rattus norvegicus)
        
        MAD2 associates with the Mad1 kinetochore complex (Rattus norvegicus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Rattus norvegicus)
        
        Mad1:kinetochore complex [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        PP2A [cytosol] (Rattus norvegicus)
        
        PP2A-catalytic subunit C [cytosol] (Rattus norvegicus)
        
        Ppp2ca [cytosol] (Rattus norvegicus)
        
        Mad1:kinetochore complex [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        PP2A [cytosol] (Rattus norvegicus)
        
        PP2A-catalytic subunit C [cytosol] (Rattus norvegicus)
        
        Ppp2ca [cytosol] (Rattus norvegicus)
        
        MAD2 converted to an inhibitory state via interaction with Mad1 (Rattus norvegicus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Rattus norvegicus)
        
        Mad1:kinetochore complex [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        PP2A [cytosol] (Rattus norvegicus)
        
        PP2A-catalytic subunit C [cytosol] (Rattus norvegicus)
        
        Ppp2ca [cytosol] (Rattus norvegicus)
        
        Mad1 binds kinetochore (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        PP2A [cytosol] (Rattus norvegicus)
        
        PP2A-catalytic subunit C [cytosol] (Rattus norvegicus)
        
        Ppp2ca [cytosol] (Rattus norvegicus)
        
        Mad1:kinetochore complex [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        PP2A [cytosol] (Rattus norvegicus)
        
        PP2A-catalytic subunit C [cytosol] (Rattus norvegicus)
        
        Ppp2ca [cytosol] (Rattus norvegicus)
        
        Release of activated MAD2 from kinetochores (Rattus norvegicus)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Rattus norvegicus)
        
        Mad1:kinetochore complex [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        PP2A [cytosol] (Rattus norvegicus)
        
        PP2A-catalytic subunit C [cytosol] (Rattus norvegicus)
        
        Ppp2ca [cytosol] (Rattus norvegicus)
        
        Mad1:kinetochore complex [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        PP2A [cytosol] (Rattus norvegicus)
        
        PP2A-catalytic subunit C [cytosol] (Rattus norvegicus)
        
        Ppp2ca [cytosol] (Rattus norvegicus)
- Cell Cycle, Mitotic (Rattus norvegicus)
  - M Phase (Rattus norvegicus)
    - Mitotic Metaphase and Anaphase (Rattus norvegicus)
      - Mitotic Anaphase (Rattus norvegicus)
        
        Nuclear Envelope (NE) Reassembly (Rattus norvegicus)
        
        Initiation of Nuclear Envelope (NE) Reformation (Rattus norvegicus)
        
        ANKLE2 binds PP2A (Rattus norvegicus)
        
        ANKLE2:PP2A [endoplasmic reticulum membrane] (Rattus norvegicus)
        
        PP2A (Aalpha:B55alpha:Calpha) [cytosol] (Rattus norvegicus)
        
        Ppp2ca [cytosol] (Rattus norvegicus)
        
        PP2A (Aalpha:B55alpha:Calpha) [cytosol] (Rattus norvegicus)
        
        Ppp2ca [cytosol] (Rattus norvegicus)
        
        Separation of Sister Chromatids (Rattus norvegicus)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Rattus norvegicus)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        PP2A [cytosol] (Rattus norvegicus)
        
        PP2A-catalytic subunit C [cytosol] (Rattus norvegicus)
        
        Ppp2ca [cytosol] (Rattus norvegicus)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        PP2A [cytosol] (Rattus norvegicus)
        
        PP2A-catalytic subunit C [cytosol] (Rattus norvegicus)
        
        Ppp2ca [cytosol] (Rattus norvegicus)
        
        Separation of sister chromatids (Rattus norvegicus)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        PP2A [cytosol] (Rattus norvegicus)
        
        PP2A-catalytic subunit C [cytosol] (Rattus norvegicus)
        
        Ppp2ca [cytosol] (Rattus norvegicus)
        
        Sister Centromere:Kinetochore:Microtubules [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        PP2A [cytosol] (Rattus norvegicus)
        
        PP2A-catalytic subunit C [cytosol] (Rattus norvegicus)
        
        Ppp2ca [cytosol] (Rattus norvegicus)
    - Mitotic Prometaphase (Rattus norvegicus)
      - EML4 and NUDC in mitotic spindle formation (Rattus norvegicus)
        
        EML4 recruits NUDC to mitotic spindle (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        PP2A [cytosol] (Rattus norvegicus)
        
        PP2A-catalytic subunit C [cytosol] (Rattus norvegicus)
        
        Ppp2ca [cytosol] (Rattus norvegicus)
        
        p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        PP2A [cytosol] (Rattus norvegicus)
        
        PP2A-catalytic subunit C [cytosol] (Rattus norvegicus)
        
        Ppp2ca [cytosol] (Rattus norvegicus)
      - Kinetochore capture of astral microtubules (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        PP2A [cytosol] (Rattus norvegicus)
        
        PP2A-catalytic subunit C [cytosol] (Rattus norvegicus)
        
        Ppp2ca [cytosol] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        PP2A [cytosol] (Rattus norvegicus)
        
        PP2A-catalytic subunit C [cytosol] (Rattus norvegicus)
        
        Ppp2ca [cytosol] (Rattus norvegicus)
      - Resolution of Sister Chromatid Cohesion (Rattus norvegicus)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Rattus norvegicus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Rattus norvegicus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        PP2A [cytosol] (Rattus norvegicus)
        
        PP2A-catalytic subunit C [cytosol] (Rattus norvegicus)
        
        Ppp2ca [cytosol] (Rattus norvegicus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        PP2A [cytosol] (Rattus norvegicus)
        
        PP2A-catalytic subunit C [cytosol] (Rattus norvegicus)
        
        Ppp2ca [cytosol] (Rattus norvegicus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        PP2A [cytosol] (Rattus norvegicus)
        
        PP2A-catalytic subunit C [cytosol] (Rattus norvegicus)
        
        Ppp2ca [cytosol] (Rattus norvegicus)
        
        Kinetochore assembly (Rattus norvegicus)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Rattus norvegicus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        PP2A [cytosol] (Rattus norvegicus)
        
        PP2A-catalytic subunit C [cytosol] (Rattus norvegicus)
        
        Ppp2ca [cytosol] (Rattus norvegicus)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        PP2A [cytosol] (Rattus norvegicus)
        
        PP2A-catalytic subunit C [cytosol] (Rattus norvegicus)
        
        Ppp2ca [cytosol] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        PP2A [cytosol] (Rattus norvegicus)
        
        PP2A-catalytic subunit C [cytosol] (Rattus norvegicus)
        
        Ppp2ca [cytosol] (Rattus norvegicus)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Rattus norvegicus)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        PP2A [cytosol] (Rattus norvegicus)
        
        PP2A-catalytic subunit C [cytosol] (Rattus norvegicus)
        
        Ppp2ca [cytosol] (Rattus norvegicus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        PP2A [cytosol] (Rattus norvegicus)
        
        PP2A-catalytic subunit C [cytosol] (Rattus norvegicus)
        
        Ppp2ca [cytosol] (Rattus norvegicus)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Rattus norvegicus)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        PP2A [cytosol] (Rattus norvegicus)
        
        PP2A-catalytic subunit C [cytosol] (Rattus norvegicus)
        
        Ppp2ca [cytosol] (Rattus norvegicus)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Rattus norvegicus)
        
        Microtubule-bound kinetochore [cytosol] (Rattus norvegicus)
        
        Kinetochore [cytosol] (Rattus norvegicus)
        
        PP2A [cytosol] (Rattus norvegicus)
        
        PP2A-catalytic subunit C [cytosol] (Rattus norvegicus)
        
        Ppp2ca [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P63331 Ppp2ca

Gene Names

Ppp2ca

Chain

chain:1-309

Reference Genes

BioGPS Gene:24672 Ppp2ca

ENSEMBL:ENSRNOG00000005389 Ppp2ca

ENSEMBL:ENSRNOG00000056485 Ppp2ca

KEGG Gene (Rattus norvegicus):103694903 Ppp2ca

KEGG Gene (Rattus norvegicus):24672 Ppp2ca

Monarch:24672 Ppp2ca

NCBI Gene:24672 Ppp2ca

UCSC:P63331 Ppp2ca

Reference Transcript

Other Identifiers

103694903

10733417

10752268

1388805_at

1398790_at

17645691

24672

5629572

5652164

5698386

5732343

5827507

5856220

5994459

6170287

6170595

6218306

6320802

6390871

6576250

6588379

6666953

A_44_P273989

A_44_P273990

A_44_P591583

GE18834

GE20296

GE22108

GO:0003674

GO:0016787

ILMN_1358097

PH_rn_0006670

X16043cds_at

rc_AI009467_at

rc_AI012595_at

Participates

as a component of

PP2A (Aalpha:B55alpha:Calpha) [cytosol] (Rattus norvegicus)

as a member of

PP2A (Calpha/Cbeta) [cytosol] (Rattus norvegicus)

as a candidate of

PP2A-catalytic subunit C [cytosol] (Rattus norvegicus)

Other forms of this molecule

phospho-Ppp2ca [cytosol]

Ppp2ca [nucleoplasm]

rPP2A-catalytic subunit C alpha isoform [cytosol]

rPP2A-catalytic subunit C alpha isoform [nucleoplasm]

Ppp2ca [nucleoplasm]

Inferred From

PPP2CA [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_058735.1, XP_008772116.1

IntEnz

3.1.3.16

Ensembl

ENSRNOT00000007621, ENSRNOT00000079985, ENSRNOG00000056485, ENSRNOP00000071286, ENSRNOG00000005389, ENSRNOP00000007621

PRO

P63331

RGD

3380

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:D3ZS28	2	Rbl1 [nucleoplasm] (R-RNO-389104) phospho-Rbl1 [nucleoplasm] (R-RNO-1226085)	0.499	2

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