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phospho-p-S222,S226-MAP2K2 [cytosol]
Stable Identifier
R-RNO-169292
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
P36506
Locations in the PathwayBrowser
Expand all
Signal Transduction (Rattus norvegicus)
MAPK family signaling cascades (Rattus norvegicus)
MAPK1/MAPK3 signaling (Rattus norvegicus)
RAF/MAP kinase cascade (Rattus norvegicus)
MAP2K and MAPK activation (Rattus norvegicus)
Dissociation of RAS:RAF complex (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
p-2S MAP2K homo/heterodimers [cytosol] (Rattus norvegicus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
p-S222,S226 MAP2K2 dimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
p-2S MAP2K homo/heterodimers [cytosol] (Rattus norvegicus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
p-S222,S226 MAP2K2 dimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
Dual mechanism MAPK inhibitors bind MAPKs (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
p-2S MAP2K homo/heterodimers [cytosol] (Rattus norvegicus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
p-S222,S226 MAP2K2 dimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
p-2S MAP2K homo/heterodimers [cytosol] (Rattus norvegicus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
p-S222,S226 MAP2K2 dimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
IL17RD binds p-2S MAP2Ks and MAPKs (Rattus norvegicus)
IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane] (Rattus norvegicus)
p-2S MAP2K homo/heterodimers [cytosol] (Rattus norvegicus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
p-S222,S226 MAP2K2 dimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
p-2S MAP2K homo/heterodimers [cytosol] (Rattus norvegicus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
p-S222,S226 MAP2K2 dimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Rattus norvegicus)
WDR83:LAMTOR2:LAMTOR3:activated RAF:p-2S MAP2K:p-T,Y MAPK complex [endosome membrane] (Rattus norvegicus)
p-2S MAP2K homo/heterodimers [cytosol] (Rattus norvegicus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
p-S222,S226 MAP2K2 dimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
MAP2Ks phosphorylate MAPK at the Golgi membrane (Rattus norvegicus)
IL17RD:p-2S MAP2Ks:MAPKs [Golgi membrane] (Rattus norvegicus)
p-2S MAP2K homo/heterodimers [cytosol] (Rattus norvegicus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
p-S222,S226 MAP2K2 dimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
IL17RD:p-2S MAP2Ks:p-T,Y MAPKs [Golgi membrane] (Rattus norvegicus)
p-2S MAP2K homo/heterodimers [cytosol] (Rattus norvegicus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
p-S222,S226 MAP2K2 dimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
p-2S MAP2K homo/heterodimers [cytosol] (Rattus norvegicus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
p-S222,S226 MAP2K2 dimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
MAP2Ks phosphorylate MAPKs (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
p-2S MAP2K homo/heterodimers [cytosol] (Rattus norvegicus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
p-S222,S226 MAP2K2 dimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
p-2S MAP2K homo/heterodimers [cytosol] (Rattus norvegicus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
p-S222,S226 MAP2K2 dimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
p-2S MAP2K homo/heterodimers [cytosol] (Rattus norvegicus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
p-S222,S226 MAP2K2 dimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
p-2S MAP2K homo/heterodimers [cytosol] (Rattus norvegicus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
p-S222,S226 MAP2K2 dimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
p-2S MAP2K homo/heterodimers [cytosol] (Rattus norvegicus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
p-S222,S226 MAP2K2 dimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
RAF phosphorylates MAP2K dimer (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
p-2S MAP2K homo/heterodimers [cytosol] (Rattus norvegicus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
p-S222,S226 MAP2K2 dimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
p-2S MAP2K homo/heterodimers [cytosol] (Rattus norvegicus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
p-S222,S226 MAP2K2 dimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Rattus norvegicus)
p-2S MAP2K homo/heterodimers [cytosol] (Rattus norvegicus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
p-S222,S226 MAP2K2 dimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
p-2S MAP2K homo/heterodimers [cytosol] (Rattus norvegicus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
p-S222,S226 MAP2K2 dimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Rattus norvegicus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Rattus norvegicus)
p-2S MAP2K homo/heterodimers [cytosol] (Rattus norvegicus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
p-S222,S226 MAP2K2 dimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
Negative regulation of MAPK pathway (Rattus norvegicus)
Negative feedback regulation of MAPK pathway (Rattus norvegicus)
Activated MAPKs phosphorylate MAP2K1 (Rattus norvegicus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
p-2S,T MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
RAF activation (Rattus norvegicus)
Phosphorylation of RAF (Rattus norvegicus)
RAF activating kinases [plasma membrane] (Rattus norvegicus)
p-2S MAP2K homo/heterodimers [cytosol] (Rattus norvegicus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
p-S222,S226 MAP2K2 dimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
Signaling by Receptor Tyrosine Kinases (Rattus norvegicus)
Signaling by NTRKs (Rattus norvegicus)
Signaling by NTRK1 (TRKA) (Rattus norvegicus)
Signalling to ERKs (Rattus norvegicus)
Prolonged ERK activation events (Rattus norvegicus)
Frs2-mediated activation (Rattus norvegicus)
Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Rattus norvegicus)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Rattus norvegicus)
p-2S MAP2K homo/heterodimers [cytosol] (Rattus norvegicus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
p-S222,S226 MAP2K2 dimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
Dissociation of phosphorylated MAP2Ks and MAPKs (Rattus norvegicus)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Rattus norvegicus)
p-2S MAP2K homo/heterodimers [cytosol] (Rattus norvegicus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
p-S222,S226 MAP2K2 dimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
p-2S MAP2K homo/heterodimers [cytosol] (Rattus norvegicus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
p-S222,S226 MAP2K2 dimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Rattus norvegicus)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Rattus norvegicus)
p-2S MAP2K homo/heterodimers [cytosol] (Rattus norvegicus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
p-S222,S226 MAP2K2 dimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Rattus norvegicus)
p-2S MAP2K homo/heterodimers [cytosol] (Rattus norvegicus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
p-S222,S226 MAP2K2 dimer [cytosol] (Rattus norvegicus)
phospho-p-S222,S226-MAP2K2 [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:P36506
Reference Genes
BioGPS Gene:58960
ENSEMBL:ENSRNOG00000020005
KEGG Gene (Rattus norvegicus):58960
Monarch:58960
NCBI Gene:58960
UCSC:P36506
Reference Transcript
RefSeq:NM_133283.1
Participates
as a component of
p-2S,T MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Rattus norvegicus)
p-S222,S226 MAP2K2 dimer [cytosol] (Rattus norvegicus)
p-2S MAP2K1:p-2S MAPK2K2 heterodimer [cytosol] (Rattus norvegicus)
Other forms of this molecule
phospho-p-S,T-MAP2K2 [cytosol]
MAP2K2 [cytosol]
Inferred From
p-S222,S226-MAP2K2 [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 222 (in Homo sapiens)
Coordinate
222
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 226 (in Homo sapiens)
Coordinate
226
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_579817.1
PRO
P36506
RGD
61888
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