Reactome | Eps15l1 [plasma membrane]

Eps15l1 [plasma membrane]

Stable Identifier

R-RNO-182937

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

plasma membrane

Synonyms

EPS15L1, A0A8I6A726

Locations in the PathwayBrowser

Expand all

Vesicle-mediated transport (Rattus norvegicus)

- Membrane Trafficking (Rattus norvegicus)
  - Clathrin-mediated endocytosis (Rattus norvegicus)
    - BAR domain proteins recruit dynamin (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Rattus norvegicus)
        
        Eps15l1 [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Rattus norvegicus)
        
        Eps15l1 [plasma membrane] (Rattus norvegicus)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Rattus norvegicus)
      - CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Rattus norvegicus)
        
        Eps15l1 [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Rattus norvegicus)
        
        Eps15l1 [plasma membrane] (Rattus norvegicus)
    - Cargo recognition for clathrin-mediated endocytosis (Rattus norvegicus)
      - Epsin family proteins bind ubiquitinated cargo (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Rattus norvegicus)
        
        Eps15l1 [plasma membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Rattus norvegicus)
        
        Eps15l1 [plasma membrane] (Rattus norvegicus)
    - Clathrin recruits PIK3C2A (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Rattus norvegicus)
        
        Eps15l1 [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Rattus norvegicus)
        
        Eps15l1 [plasma membrane] (Rattus norvegicus)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Rattus norvegicus)
        
        Eps15l1 [plasma membrane] (Rattus norvegicus)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Rattus norvegicus)
        
        Eps15l1 [plasma membrane] (Rattus norvegicus)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Rattus norvegicus)
        
        Eps15l1 [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Rattus norvegicus)
        
        Eps15l1 [plasma membrane] (Rattus norvegicus)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Rattus norvegicus)
        
        Eps15l1 [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Rattus norvegicus)
        
        Eps15l1 [plasma membrane] (Rattus norvegicus)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Rattus norvegicus)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Rattus norvegicus)
        
        Eps15l1 [plasma membrane] (Rattus norvegicus)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Rattus norvegicus)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        CLASP proteins:cargo [plasma membrane] (Rattus norvegicus)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        ubiquitinated cargo [plasma membrane] (Rattus norvegicus)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Rattus norvegicus)
        
        Eps15l1 [plasma membrane] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:A0A8I6A726

Gene Names

Eps15l1

Reference Genes

BioGPS Gene:361120 Eps15l1

ENSEMBL:ENSRNOG00000013502

Monarch:361120 Eps15l1

NCBI Gene:361120 Eps15l1

UCSC:A0A8I6A726 Eps15l1

Reference Transcript

RefSeq:XM_006252802.3 Eps15l1

Other Identifiers

10787162

1373323_at

17706726

361120

5664294

5674186

5735209

5745587

5828468

5906830

5928938

5935659

5943423

5952412

6010085

6039552

6094544

6129579

6152847

6197103

6257954

6258412

6333623

6337380

6379067

6379539

6403395

6421819

6432293

6437358

6518882

6526333

6629813

6639066

6664580

6676180

6719944

A_44_P323696

GE1135265

GE1277963

GO:0005509

GO:0005515

GO:0005886

GO:0030132

ILMN_1370498

PH_rn_0008192

rc_AI231925_at

Participates

as a component of

as an input of

Other forms of this molecule

Eps15l1 [cytosol]

Inferred From

EPS15L1 [plasma membrane] (Homo sapiens)

Cross References

ENSEMBL

ENSRNOP00000088897, ENSRNOT00000104367, ENSRNOG00000013502

RGD

1565708

Cite Us!