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phospho-p-6Y-SYK [cytosol]
Stable Identifier
R-RNO-1861712
Type
Protein [EntityWithAccessionedSequence]
Species
Rattus norvegicus
Compartment
cytosol
Synonyms
Q64725
Locations in the PathwayBrowser
Expand all
Immune System (Rattus norvegicus)
Adaptive Immune System (Rattus norvegicus)
Signaling by the B Cell Receptor (BCR) (Rattus norvegicus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Rattus norvegicus)
BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate (Rattus norvegicus)
BLNK (SLP-65) Signalosome [plasma membrane] (Rattus norvegicus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
Antigen:p-BCR:p-SYK [plasma membrane] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
BTK binds BTK inhibitors (Rattus norvegicus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Rattus norvegicus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
Antigen:p-BCR:p-SYK [plasma membrane] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
BTK:BTK inhibitors [plasma membrane] (Rattus norvegicus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Rattus norvegicus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
Antigen:p-BCR:p-SYK [plasma membrane] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (Rattus norvegicus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
Antigen:p-BCR:p-SYK [plasma membrane] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] (Rattus norvegicus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
Antigen:p-BCR:p-SYK [plasma membrane] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
SYK autophosphorylates at the activated BCR (Rattus norvegicus)
Antigen:p-BCR:p-SYK [plasma membrane] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
p-6Y-SYK phosphorylates BLNK (SLP65) (Rattus norvegicus)
Antigen:p-BCR:p-SYK [plasma membrane] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] (Rattus norvegicus)
Antigen:p-BCR:p-SYK [plasma membrane] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
Innate Immune System (Rattus norvegicus)
C-type lectin receptors (CLRs) (Rattus norvegicus)
Dectin-2 family (Rattus norvegicus)
PLCG2 translocates from cytosol to plasma membrane (Rattus norvegicus)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:p-Y753,Y759-PLCG2 [plasma membrane] (Rattus norvegicus)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
SYK autophosphorylates (Rattus norvegicus)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2 (Rattus norvegicus)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:PLCG2 [plasma membrane] (Rattus norvegicus)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK:p-Y753,Y759-PLCG2 [plasma membrane] (Rattus norvegicus)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
DAP12 interactions (Rattus norvegicus)
DAP12 signaling (Rattus norvegicus)
PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
Phosphorylation and activation of VAV2/VAV3 by SYK (Rattus norvegicus)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
SYK/LCK/ZAP-70 [cytosol] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
Phosphorylation of BTK by p-SYK (Rattus norvegicus)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
SYK/LCK/ZAP-70 [cytosol] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
Phosphorylation of LAT by p-SYK (Rattus norvegicus)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
SYK/LCK/ZAP-70 [cytosol] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Rattus norvegicus)
p-SYK,p-BTK [cytosol] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
p-SYK/p-BTK [plasma membrane] (Rattus norvegicus)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
Phosphorylation of SLP-76 by p-SYK (Rattus norvegicus)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
SYK/LCK/ZAP-70 [cytosol] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
Phosphorylation of SYK (Rattus norvegicus)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
p85 regulatory unit of PI3K binds p-6Y-SYK (Rattus norvegicus)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
Fc epsilon receptor (FCERI) signaling (Rattus norvegicus)
FCERI mediated Ca+2 mobilization (Rattus norvegicus)
Phosphorylation of TEC kinases by p-SYK (Rattus norvegicus)
Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
FCERI mediated MAPK activation (Rattus norvegicus)
Phosphorylation of SHC by SYK kinase (Rattus norvegicus)
Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
Phosphorylation of SLP-76 by p-SYK (Rattus norvegicus)
Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
Phosphorylation of LAT by p-SYK (Rattus norvegicus)
Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
Role of LAT2/NTAL/LAB on calcium mobilization (Rattus norvegicus)
Phosphorylation of NTAL by p-SYK/Lyn (Rattus norvegicus)
Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
Fcgamma receptor (FCGR) dependent phagocytosis (Rattus norvegicus)
Regulation of actin dynamics for phagocytic cup formation (Rattus norvegicus)
Activation of RAC1 by CRKII:DOCK180:ELMO (Rattus norvegicus)
CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Rattus norvegicus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
Activation of RAC1 by VAV (Rattus norvegicus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAV [plasma membrane] (Rattus norvegicus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
Phosphorylation of VAV (Rattus norvegicus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Rattus norvegicus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-VAV [plasma membrane] (Rattus norvegicus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
Recruitment of VAV1 to p-6Y-SYK (Rattus norvegicus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:VAV [plasma membrane] (Rattus norvegicus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
Role of phospholipids in phagocytosis (Rattus norvegicus)
PI3K binds to p-6Y-SYK (Rattus norvegicus)
PI3K:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
PI3K phosphorylates PIP2 to PIP3 (Rattus norvegicus)
PI3K:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
Phosphorylation and activation of PLCG (Rattus norvegicus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane] (Rattus norvegicus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Rattus norvegicus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
Recruitment of PLCgamma to membrane (Rattus norvegicus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:PLCG [plasma membrane] (Rattus norvegicus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
Release of PLCG from FCGR (Rattus norvegicus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK:p-3Y-PLCG [plasma membrane] (Rattus norvegicus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
phospho-p-6Y-SYK [cytosol] (Rattus norvegicus)
External Reference Information
External Reference
UniProt:Q64725 Syk
Gene Names
Syk
Chain
chain:1-629
Reference Genes
BioGPS Gene:25155 Syk
KEGG:rno:25155 Syk
Monarch:25155 Syk
NCBI Gene:25155 Syk
UCSC:Q64725 Syk
Reference Transcript
RefSeq:NM_012758.1 Syk
Participates
as a member of
p-SYK,p-BTK [cytosol] (Rattus norvegicus)
SYK/LCK/ZAP-70 [cytosol] (Rattus norvegicus)
as a component of
DAP12 Receptors:p-DAP12:p-6Y-SYK:PI3K [plasma membrane] (Rattus norvegicus)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
DAP12 Receptors:p-DAP12:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
Clustered p:LYN:p-FCERI:IgE:allergen:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
Antigen:p-BCR:p-SYK [plasma membrane] (Rattus norvegicus)
clustered IgG-Ag:p-FCGRs:p-6Y-SYK [plasma membrane] (Rattus norvegicus)
Other forms of this molecule
phospho-p-Y-SYK [cytosol]
phospho-p-Y-SYK [plasma membrane]
p-317Y,519Y,520Y-Syk [cytosol]
Syk [cytosol]
phospho-p-Y348-SYK [cytosol]
SYK [cytosol]
Inferred From
p-6Y-SYK [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at 348 (in Homo sapiens)
Coordinate
348
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 352 (in Homo sapiens)
Coordinate
352
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 525 (in Homo sapiens)
Coordinate
525
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 526 (in Homo sapiens)
Coordinate
526
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 131 (in Homo sapiens)
Coordinate
131
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 323 (in Homo sapiens)
Coordinate
323
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_036890.1
ZINC - Investigational
KSYK_RAT
ZINC - Metabolites
KSYK_RAT
ZINC - World Drugs
KSYK_RAT
ZINC - Substances
KSYK_RAT
ZINC - Biogenic
KSYK_RAT
ZINC target
Q64725
PRO
Q64725
RGD
3796
ZINC - Predictions - Purchasable
KSYK_RAT
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